Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)

NCT06615050 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to assess Tacrolimus/Methotrexate/Ruxolitinib versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation

Interventions

  • DRUG Cyclophosphamide
  • DRUG Methotrexate (MTX)
  • DRUG Tacrolimus (Tac)
  • DRUG Ruxolitinib (Rux)
  • DRUG Mycophenolate mofetil (MMF)

Study Locations (20)

Michigan

  • University of Michigan — Ann Arbor
  • Karmanos Cancer Institute — Detroit
  • Henry Ford Hospital — Detroit

North Carolina

  • University of North Carolina At Chapel Hill — Chapel Hill
  • Levine Cancer Institute — Charlotte
  • Duke University Medical Center — Durham

California

  • Stanford Cancer Center — Palo Alto
  • University of California San Francisco — San Francisco

Florida

  • University of Miami — Miami
  • Moffitt Cancer Center — Tampa

New York

  • Mount Sinai Hospital — New York
  • Memorial Sloan Kettering — New York

Ohio

  • Cleveland Clinic — Cleveland
  • Ohio State University — Columbus

Georgia

  • Blood and Marrow Transplant Group of Georgia — Atlanta

Indiana

  • Indiana University Cancer Center — Indianapolis

Trial Details

FieldValue
Enrollment Target 572 participants
Start Date 2025-04-02
Est. Completion 2031-01-17
Phase Phase 3

Sponsor

Incyte Corporation

163 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06615050

The ClinicalTrials.gov registry entry for NCT06615050 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 572 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Incyte Corporation, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Graft-versus-host Disease (GVHD) appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06615050 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Michigan, North Carolina, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06615050 about?

NCT06615050 is a clinical study titled "A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)". The purpose of this study is to assess Tacrolimus/Methotrexate/Ruxolitinib versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation

What is the current status of trial NCT06615050?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 572 participants. The study started on 2025-04-02. Estimated completion is 2031-01-17.

What conditions does trial NCT06615050 study?

This clinical trial studies the following conditions: Graft-versus-host Disease (GVHD). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06615050?

The interventions under investigation include: Cyclophosphamide (DRUG), Methotrexate (MTX) (DRUG), Tacrolimus (Tac) (DRUG), Ruxolitinib (Rux) (DRUG), Mycophenolate mofetil (MMF) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06615050?

This trial is sponsored by Incyte Corporation, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06615050 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Indiana, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial