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NCT06574048 · ClinicalTrials.gov registry record · Phase 1
Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy
A Phase 1 study, sponsored by University of Nebraska.
- Not yet
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT06574048: Clinical Trial Phase 1 study, sponsored by University of Nebraska.
NCT06574048 is a Phase 1 study that has not yet begun recruiting, run by University of Nebraska. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06574048, a Phase 1 study, has not yet begun recruiting, sponsored by University of Nebraska.
- NOT YET RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instigate a demyelinating process resulting in long term neurological sequelae in some, but not all patients. In other demyelinating disorders, steroids are a part of first line treatment. HBO is already used for acute CO poisoning, so this pilot study will try to ascertain if the addition of steroids in concert with each hyperbaric oxygen session will yield improved outcomes.
Primary Outcome
The Montreal Cognitive Assessment (MoCA) is a rapid screening instrument for mild cognitive dysfunction that assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuo-constructional skills, conceptual thinking, calculations, and orientation. The MoCA will be given in person while inpatient and via phone after discharge. Scored 0-30 Normal Cognitive performance 26 and above Mild impairment 18-25 Moderate impairment 10-17 Severe impairment 0-9
Interventions
- DRUG Dexamethasone
- DRUG saline placebo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-07 |
| Est. Completion | 2028-01 |
| Phase | Phase 1 |
What is known before NCT06574048 opens enrollment
NCT06574048 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 2 interventions - of which Dexamethasone is the first listed.
NCT06574048 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06574048 about?
NCT06574048 is a clinical study titled "Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy". Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instig...
What is the current status of trial NCT06574048?
This trial is currently not yet recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2026-07. Estimated completion is 2028-01.
What interventions are being tested in trial NCT06574048?
The interventions under investigation include: Dexamethasone (DRUG), saline placebo (DRUG).
Who is sponsoring clinical trial NCT06574048?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06574048's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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