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NCT06529809 · ClinicalTrials.gov registry record · Phase 1
Accelerated Brachytherapy Forward Chemo Radiation Therapy (ABC-RT) for Locally-advanced Cervical Cancer
A Phase 1 study of Locally Advanced Cervical Carcinoma, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06529809: Recruiting Phase 1 study of Locally Advanced Cervical Carcinoma, sponsored by Washington University School of Medicine.
NCT06529809 is a Phase 1 study of Locally Advanced Cervical Carcinoma that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 50 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06529809, a Phase 1 study of Locally Advanced Cervical Carcinoma, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The standard treatment for locally advanced cervical cancer is well established as a combination of chemotherapy and radiation, typically over 25-28 daily fractions with the addition of a brachytherapy boost to the primary tumor. An important component to treatment efficacy is overall treatment time. Prolongation of overall treatment time has been shown to lead to worse local control and overall survival; thus, strategies to effectively deliver radiation efficiently is required. This is a pragmatic feasibility study to determine the impact of upfront brachytherapy combined with hypofractionated external beam radiation for patients with locally advanced cervical cancer (FIGO 2018 stage IB3-IVA) on late gastrointestinal and genitourinary toxicity, oncologic outcomes including recurrence free survival, and systemic and local immune response.
Primary Outcome
-Must be at least possibly related to RT.
Conditions Studied
Interventions
- DRUG Chemotherapy
- RADIATION Hypofractionated external beam radiation
- RADIATION Image-guided brachytherapy
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-02-11 |
| Est. Completion | 2031-12-31 |
| Phase | Phase 1 |
What NCT06529809 shows while recruiting
NCT06529809 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% lower).
The record links to 1 condition, with Locally Advanced Cervical Carcinoma appearing as the primary indexed condition, and to 3 interventions - of which Chemotherapy is the first listed.
NCT06529809 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT06529809 about?
NCT06529809 is a clinical study titled "Accelerated Brachytherapy Forward Chemo Radiation Therapy (ABC-RT) for Locally-advanced Cervical Cancer". The standard treatment for locally advanced cervical cancer is well established as a combination of chemotherapy and radiation, typically over 25-28 daily fractions with the addition of a brachytherapy boost to the primary tumor. An important component to treatment efficacy is overall treatment time...
What is the current status of trial NCT06529809?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2025-02-11. Estimated completion is 2031-12-31.
What conditions does trial NCT06529809 study?
This clinical trial studies the following conditions: Locally Advanced Cervical Carcinoma.
What interventions are being tested in trial NCT06529809?
The interventions under investigation include: Chemotherapy (DRUG), Hypofractionated external beam radiation (RADIATION), Image-guided brachytherapy (RADIATION).
Who is sponsoring clinical trial NCT06529809?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06529809 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06529809's enrollment target sits among peer trials
50 973rd of 2000 higher than 984 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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