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NCT06516965 · ClinicalTrials.gov registry record · Phase 3
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2)
A Phase 3 study of Prurigo Nodularis, sponsored by Incyte Corporation.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 330
- Enrollment target
- 20
- Study locations
NCT06516965: Recruiting Phase 3 study of Prurigo Nodularis, sponsored by Incyte Corporation.
NCT06516965 is a Phase 3 study of Prurigo Nodularis that is actively recruiting participants, run by Incyte Corporation. The registered enrollment target is 330 participants, above the 206-participant average among 14 other Prurigo Nodularis trials with a reported enrollment target (60% higher). The trial reports 20 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06516965, a Phase 3 study of Prurigo Nodularis, is actively recruiting participants, sponsored by Incyte Corporation.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 330 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to evaluate effect of povorcitinib on itch and skin lesions in participants with prurigo nodularis.
Primary Outcome
Defined as proportion of participants achieving a ≥ 4-point improvement \[reduction\] in Itch NRS score from baseline (Itch NRS4) and an IGA CPG-S score of 0 or 1 with a ≥ 2-grade improvement from baseline (IGA-CPG-S-TS).
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Povorcitinib
Study Locations (20)
Florida
- Center For Clinical and Cosmetic Research - Aventura
- Schweiger Dermatology - Boca Raton
- Direct Helpers Research Center - Hialeah
- Skin Care Research, Llc - Hollywood
- Ziaderm Research, Llc - Miami
- Nodal Medical Center, Llc - Tampa
- Trueblue Clinical Research Moore Clinical Research, Inc McR Tampa Clinic Location - Tampa
Michigan
- Fivenson Dermatology - Ann Arbor
- Henry Ford Health System - Detroit
- Michigan Dermatology Institute - Waterford
Arizona
- Medical Dermatology Specialists Phoenix - Phoenix
- Investigate Md - Scottsdale
California
- First Oc Dermatology Research Inc - Fountain Valley
- Clinical Science Institute Clinical Research Specialists Inc - Santa Monica
Maryland
- University of Maryland School of Medicine - Baltimore
- Dermatology Associates Pc - Rockville
Kentucky
- Dermatology Specialists Research - Louisville
Massachusetts
- Metro Boston Clinical Partners - Brighton
New Hampshire
- Allcutis Research, Llc - Portsmouth
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 330 participants |
| Start Date | 2024-10-10 |
| Est. Completion | 2027-05-03 |
| Phase | Phase 3 |
What NCT06516965 shows while recruiting
NCT06516965 is an interventional study that assigns participants to a tested intervention. The registered 330 participants enrollment target is mid-sized for trials with a published cap, above the 206-participant average among 14 other Prurigo Nodularis trials with a reported enrollment target (60% higher).
The record links to 1 condition, with Prurigo Nodularis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06516965 names 20 study sites across 9 states, led by Florida, Michigan, Arizona.
Frequently Asked Questions
What is clinical trial NCT06516965 about?
NCT06516965 is a clinical study titled "A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2)". The purpose of this study is to evaluate effect of povorcitinib on itch and skin lesions in participants with prurigo nodularis.
What is the current status of trial NCT06516965?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 330 participants. The study started on 2024-10-10. Estimated completion is 2027-05-03.
What conditions does trial NCT06516965 study?
This clinical trial studies the following conditions: Prurigo Nodularis.
What interventions are being tested in trial NCT06516965?
The interventions under investigation include: Placebo (DRUG), Povorcitinib (DRUG).
Who is sponsoring clinical trial NCT06516965?
This trial is sponsored by Incyte Corporation, which has 239 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06516965 being conducted?
This trial has 20 study locations across Arizona, California, Florida, Kentucky, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Prurigo Nodularis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06516965's enrollment target sits among peer trials
330 4th of 14 higher than 10 of 14 other Prurigo Nodularis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Prurigo Nodularis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study to Investigate the Pharmacokinetics and Safety of Dupilumab in Participants ≥6 Months to <18 Years of Age With Prurigo Nodularis
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A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)
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