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NCT06394401 · ClinicalTrials.gov registry record · NA
Optimized Carbohydrate Fueling to Enhance Physical Performance During Energy Deficit
A NA study of Energy Supply; Deficiency, sponsored by United States Army Research Institute of Environmental Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT06394401 is a NA study of Energy Supply; Deficiency that is actively recruiting participants, run by United States Army Research Institute of Environmental Medicine. The registered enrollment target is 12 participants. The trial reports 1 study location across 1 state.
The verdict
NCT06394401, a NA study of Energy Supply; Deficiency, is actively recruiting participants, sponsored by United States Army Research Institute of Environmental Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
This randomized crossover study will examine the effects of consuming isocaloric GLU+FRU or GLU alone on rates of exogenous carbohydrate oxidation during aerobic exercise and physical performance (time trial) under energy balance (BAL) and energy deficit (DEF). Baseline data will be collected on volunteer height, weight, body composition, and V̇O2peak. To ensure volunteers are familiar with exercise protocols, they will complete practice sessions of all exercise before the start of data collection. Exercise and diet will be controlled throughout data collection. To start the protocol volunteers will complete a bout of glycogen normalization on a cycle ergometer followed by 48 hours of refeeding at 100% (BAL) or 50% (DEF) of their energy needs. After the 48 hours of refeeding volunteers will return to the laboratory to complete 80 min of steady-state (60 ± 5% V̇O2peak) exercise on a cycle ergometer. Immediately before and during steady-state exercise, volunteers will consume either 80 g of GLU+FRU (53 g glucose + 27 g fructose) or 80 g GLU. Drinks containing corn-derived crystalline fructose (KRYSTAR® 300, Tate and Lyle Sugars, London, UK) and glucose (CERELOSE®, Ingredion, Westchester, IL, USA) will be prepared by unblinded USARIEM staff. Drinks will be enriched with 13C stable isotopes (Cambridge Isotope Laboratory, Andover, MA, USA) to measure exogenous and plasma carbohydrate oxidation during steady-state exercise. After steady-state exercise, physical performance will be assessed using a graded exercise test on a stationary bike. Indirect calorimetry and breath sampling will be used to determine substrate oxidation during steady-state exercise. Serial blood draws will be collected during each trial to assess isotope enrichments, and circulating substrate/hormone responses. Muscle biopsies will be performed before and after steady-state exercise to assess glycogen status, enzyme activity, and molecular regulation of substrate metabolism. There will be a minimum o
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT BAL:GLU
- DIETARY_SUPPLEMENT BAL:GLU+FRU
- DIETARY_SUPPLEMENT DEF:GLU
- DIETARY_SUPPLEMENT DEF:GLU+FRU
Study Locations (1)
Massachusetts
- USARIEM - Natick
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2024-02-01 |
| Est. Completion | 2024-12-01 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06394401
The ClinicalTrials.gov registry entry for NCT06394401 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is United States Army Research Institute of Environmental Medicine, which has 59 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Energy Supply; Deficiency appearing as the primary indexed condition, and to 4 interventions - of which BAL:GLU is the first listed.
NCT06394401 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06394401 about?
NCT06394401 is a clinical study titled "Optimized Carbohydrate Fueling to Enhance Physical Performance During Energy Deficit". This randomized crossover study will examine the effects of consuming isocaloric GLU+FRU or GLU alone on rates of exogenous carbohydrate oxidation during aerobic exercise and physical performance (time trial) under energy balance (BAL) and energy deficit (DEF). Baseline data will be collected on vol...
What is the current status of trial NCT06394401?
This trial is currently recruiting. It is a NA study. The enrollment target is 12 participants. The study started on 2024-02-01. Estimated completion is 2024-12-01.
What conditions does trial NCT06394401 study?
This clinical trial studies the following conditions: Energy Supply; Deficiency.
What interventions are being tested in trial NCT06394401?
The interventions under investigation include: BAL:GLU (DIETARY_SUPPLEMENT), BAL:GLU+FRU (DIETARY_SUPPLEMENT), DEF:GLU (DIETARY_SUPPLEMENT), DEF:GLU+FRU (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06394401?
This trial is sponsored by United States Army Research Institute of Environmental Medicine, which has 59 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06394401 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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