Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia

NCT06311227 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial tests how well venetoclax works in treating patients with hairy cell leukemia that has come back after a period of improvement (relapsed). Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival.

Interventions

  • PROCEDURE Biospecimen Collection
  • PROCEDURE Bone Marrow Aspiration
  • PROCEDURE Bone Marrow Biopsy
  • PROCEDURE Computed Tomography
  • PROCEDURE Lumbar Puncture

Study Locations (20)

Florida

  • UM Sylvester Comprehensive Cancer Center at Aventura — Aventura
  • UM Sylvester Comprehensive Cancer Center at Coral Gables — Coral Gables
  • UM Sylvester Comprehensive Cancer Center at Coral Springs — Coral Springs
  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach
  • UM Sylvester Comprehensive Cancer Center at Doral — Doral
  • UM Sylvester Comprehensive Cancer Center at Hollywood — Hollywood
  • University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami
  • UM Sylvester Comprehensive Cancer Center at Kendall — Miami

Kansas

  • University of Kansas Cancer Center — Kansas City
  • University of Kansas Cancer Center-Overland Park — Overland Park
  • University of Kansas Hospital-Westwood Cancer Center — Westwood

Missouri

  • University of Kansas Cancer Center - Briarcliff — Kansas City
  • University of Kansas Cancer Center - North — Kansas City
  • University of Kansas Cancer Center - Lee's Summit — Lee's Summit

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • City of Hope at Irvine Lennar — Irvine

Maryland

  • University of Maryland/Greenebaum Cancer Center — Baltimore
  • NCI - Center for Cancer Research — Bethesda

Ohio

  • University of Cincinnati Cancer Center-UC Medical Center — Cincinnati
  • Ohio State University Comprehensive Cancer Center — Columbus

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2024-12-16
Est. Completion 2027-05-20
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06311227

The ClinicalTrials.gov registry entry for NCT06311227 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Recurrent Hairy Cell Leukemia appearing as the primary indexed condition, and to 5 interventions — of which Biospecimen Collection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06311227 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Florida, Kansas, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06311227 about?

NCT06311227 is a clinical study titled "Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia". This phase II trial tests how well venetoclax works in treating patients with hairy cell leukemia that has come back after a period of improvement (relapsed). Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2...

What is the current status of trial NCT06311227?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2024-12-16. Estimated completion is 2027-05-20.

What conditions does trial NCT06311227 study?

This clinical trial studies the following conditions: Recurrent Hairy Cell Leukemia, Recurrent Hairy Cell Leukemia Variant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06311227?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Bone Marrow Aspiration (PROCEDURE), Bone Marrow Biopsy (PROCEDURE), Computed Tomography (PROCEDURE), Lumbar Puncture (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06311227?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06311227 being conducted?

This trial has 20 study locations across California, Florida, Kansas, Maryland, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial