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NCT06270576 · ClinicalTrials.gov registry record · Phase 1
Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma
A Phase 1 study, sponsored by National Jewish Health.
- Not yet
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
NCT06270576: Clinical Trial Phase 1 study, sponsored by National Jewish Health.
NCT06270576 is a Phase 1 study that has not yet begun recruiting, run by National Jewish Health. The registered enrollment target is 60 participants, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06270576, a Phase 1 study, has not yet begun recruiting, sponsored by National Jewish Health.
- NOT YET RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
Study Summary
A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma.
Primary Outcome
Neutrophil subset composition as determined by single cell RNAseq is compared to endotype groups using a multivariate linear regression framework for compositional data, employing the additive log ratio transformation. Models will include indicator variables for whether a sample is T1 high, T2 high, T17 high or non-asthmatic and will control for age, sex, and smoking status. AM subset gene expression matrices from scRNAseq will be compared between endotypes using the pseudo bulk approach to acco
Interventions
- DRUG Lipopolysaccharides
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-04 |
| Est. Completion | 2028-06 |
| Phase | Phase 1 |
What is known before NCT06270576 opens enrollment
NCT06270576 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target.
The record links to 0 conditions, and to 1 intervention - of which Lipopolysaccharides is the first listed.
NCT06270576 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06270576 about?
NCT06270576 is a clinical study titled "Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma". A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma.
What is the current status of trial NCT06270576?
This trial is currently not yet recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2024-04. Estimated completion is 2028-06.
What interventions are being tested in trial NCT06270576?
The interventions under investigation include: Lipopolysaccharides (DRUG).
Who is sponsoring clinical trial NCT06270576?
This trial is sponsored by National Jewish Health, which has 83 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06270576's enrollment target sits among peer trials
60 831st of 2000 higher than 1,106 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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