Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

NCT06164730 · View on ClinicalTrials.gov ↗

Study Summary

VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing Technology Designed to Disrupt the Expression of the PCSK9 Gene in the Liver and Lower Circulating PCSK9 and LDL-C. This Study is Designed to Determine the Safety and Pharmacodynamic Profile of VERVE-102 in This Patient Population.

Interventions

  • DRUG VERVE-102

Study Locations (18)

Other

  • Clinical Study Center — Adelaide
  • Clinical Study Center — Melbourne
  • Clinical Study Center — Sydney
  • Clinical Study Center — Chicoutimi
  • Clinical Study Center — Montreal
  • Clinical Study Center — Toronto
  • Clinical Study Center — Vancouver
  • Clinical Study Center — Rehovot
  • Clinical Study Center — Christchurch
  • Clinical Study Center — Birmingham
  • Clinical Study Center — Edinburgh
  • Clinical Study Center — London
  • Clinical Study Center — Manchester
  • Clinical Study Center — Nottingham

Alabama

  • Clinical Study Center — Dothan

North Carolina

  • Clinical Study Center — High Point

Texas

  • Clinical Study Center — DeSoto

Washington

  • Clinical Study Center — Renton

Trial Details

FieldValue
Enrollment Target 85 participants
Start Date 2024-04-30
Est. Completion 2027-08
Phase Phase 1

Sponsor

Verve Therapeutics

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06164730

The ClinicalTrials.gov registry entry for NCT06164730 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 85 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Verve Therapeutics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Heterozygous Familial Hypercholesterolemia appearing as the primary indexed condition, and to 1 intervention — of which VERVE-102 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06164730 reports 18 study locations spanning 5 distinct geographic areas — top geographies include Other, Alabama, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06164730 about?

NCT06164730 is a clinical study titled "A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease". VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing...

What is the current status of trial NCT06164730?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 85 participants. The study started on 2024-04-30. Estimated completion is 2027-08.

What conditions does trial NCT06164730 study?

This clinical trial studies the following conditions: Heterozygous Familial Hypercholesterolemia, Premature Coronary Heart Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06164730?

The interventions under investigation include: VERVE-102 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06164730?

This trial is sponsored by Verve Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06164730 being conducted?

This trial has 18 study locations across Alabama, North Carolina, Texas, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial