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NCT06042413 · ClinicalTrials.gov registry record · NA
Prediction and Prevention of Postoperative Mortality and Morbidity
A NA study, sponsored by University of Pittsburgh.
- Not yet
- Registry status
- NA
- Development phase
- 1,200
- Enrollment target
NCT06042413: Clinical Trial NA study, sponsored by University of Pittsburgh.
NCT06042413 is a NA study that has not yet begun recruiting, run by University of Pittsburgh. The registered enrollment target is 1,200 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (15% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06042413, a NA study, has not yet begun recruiting, sponsored by University of Pittsburgh.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 1,200 participants
- Enrollment target
Study Summary
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive outcomes following elective cardiac and vascular surgery in older adults. It will evaluate associations between perioperative factors and longer-term neurocognitive outcomes, including postoperative neurocognitive disorder and dementia. In addition, this study will assess scalable, multimodal preoperative and intraoperative interventions to improve perioperative outcomes. This study will explore two main hypotheses: 1. Preoperative personalized prehabilitation with proactive cognitive and behavioral interventions will improve postoperative cognitive outcomes, morbidity, and mortality in high-risk elderly surgical patients. 2. Proactive bundled intraoperative interventions are superior to reactive standard of care in reducing postoperative cognitive outcomes, MACCE, and mortality. Expected Outcome: Improved EHR algorithm will have higher predictive accuracy for MACCE and mortality while predicting postoperative cognitive outcomes.
Primary Outcome
Postoperative delirium will be assessed using the Confusion Assessment Method (CAM). Participants will be classified as having delirium or not having delirium based on standard CAM criteria. A positive CAM indicates the presence of delirium.
Interventions
- BEHAVIORAL Cognitive Training
- BEHAVIORAL Meditation
- OTHER Personalized CPC Prehabilitation
- BEHAVIORAL Daily Exercise
- BEHAVIORAL Enhanced Social Support
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,200 participants |
| Start Date | 2026-08 |
| Est. Completion | 2027-06 |
| Phase | NA |
What is known before NCT06042413 opens enrollment
NCT06042413 is an interventional study that assigns participants to a tested intervention. Its 1,200 participants enrollment target places it among the larger protocols in the corpus, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (15% lower).
The record links to 0 conditions, and to 5 interventions - of which Cognitive Training is the first listed.
NCT06042413 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06042413 about?
NCT06042413 is a clinical study titled "Prediction and Prevention of Postoperative Mortality and Morbidity". This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive outcomes following elective cardiac and vascular surgery in older adul...
What is the current status of trial NCT06042413?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 1,200 participants. The study started on 2026-08. Estimated completion is 2027-06.
What interventions are being tested in trial NCT06042413?
The interventions under investigation include: Cognitive Training (BEHAVIORAL), Meditation (BEHAVIORAL), Personalized CPC Prehabilitation (OTHER), Daily Exercise (BEHAVIORAL), Enhanced Social Support (BEHAVIORAL).
Who is sponsoring clinical trial NCT06042413?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06042413's enrollment target sits among peer trials
1,200 83rd of 2000 higher than 1,912 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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