Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study to Assess the Safety and Effectiveness of NMRA-335140-501
NCT06029439 · View on ClinicalTrials.gov ↗
Study Summary
This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder (MDD). Participants who completed a parent study investigating the efficacy and safety of NMRA-335140 as a treatment for MDD (ie, NMRA-335140-301, NMRA-335140-302, or NMRA-335140-303), and complete the 6 weeks double-blind treatment, provide informed consent, and meet eligibility criteria, may enter this extension study.
Conditions Studied
Interventions
- DRUG NMRA-335140
Study Locations (20)
California
- Neumora Investigator site — Bellflower
- Neumora Investigator Site — Cerritos
- Neumora Investigator Site — Encino
- Neumora Investigator Site — Garden Grove
- Neumora Investigator Site — Glendale
- Neumora Investigator Site — Imperial
- Neumora Investigator Site — Irvine
- Neumora Investigator Site — Lafayette
- Neumora Investigator Site #1 — Long Beach
- Neumora Investigator site — Long Beach
- Neumora Investigator Site — Los Angeles
- Neumora Investigator Site — Newport Beach
- Neumora Investigator Site — Oceanside
- Neumora Investigator Site #1 — Orange
Arkansas
- Neumora Investigator Site — Bentonville
- Neumora Investigator Site #1 — Little Rock
- Neumora Investigator site — Little Rock
- Neumora Investigator Site — Rogers
Alabama
- Neumora Investigator site — Huntsville
Arizona
- Neumora Investigator Site — Phoenix
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2023-11-10 |
| Est. Completion | 2027-06 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06029439
The ClinicalTrials.gov registry entry for NCT06029439 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Neumora Therapeutics, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention — of which NMRA-335140 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06029439 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Arkansas, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06029439 about?
NCT06029439 is a clinical study titled "Study to Assess the Safety and Effectiveness of NMRA-335140-501". This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder (MDD). Participants who completed a parent study investigating the efficacy and safety of NMRA-335140 as a treatment for MDD...
What is the current status of trial NCT06029439?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,000 participants. The study started on 2023-11-10. Estimated completion is 2027-06.
What conditions does trial NCT06029439 study?
This clinical trial studies the following conditions: Major Depressive Disorder. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06029439?
The interventions under investigation include: NMRA-335140 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06029439?
This trial is sponsored by Neumora Therapeutics, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06029439 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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