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NCT05983744 · ClinicalTrials.gov registry record · NA

Pulsatile Perfusion Therapy Phase II

A NA study of Hemorrhage, sponsored by Caroline Rickards.

Completed
Registry status
NA
Development phase
21
Enrollment target
1
Study location

NCT05983744 is a NA study of Hemorrhage that has completed, run by Caroline Rickards. The registered enrollment target is 21 participants, below the 266-participant average among 20 other Hemorrhage trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05983744, a NA study of Hemorrhage, has completed, sponsored by Caroline Rickards.

COMPLETED
Registry status
NA
Development phase
21 participants
Enrollment target
1
Study location

Study Summary

Individuals who suffer from a stroke, cardiac arrest, or traumatic bleeding (hemorrhage) injuries often have compromised blood flow and oxygen to the brain which can lead to the death of brain cells, and if the patient survives, subsequent difficulty in thinking and performing tasks of daily living. Traditionally, delivery of a constant flow of blood to the brain has been thought to be the most important factor for the survival of brain cells. In this study, a novel intervention will be assessed called "pulsatile perfusion therapy", delivering blood flow in a slow pulsing pattern. It is anticipated this intervention will improve brain blood flow and oxygenation during these serious clinical events. There is a specific interest in whether delivery of brain blood flow with a slow pulsatile pattern will improve oxygenation of brain tissue, particularly when the brain is challenged under low oxygen (hypoxia) and low volume (hypovolemia) conditions, simulating stroke, cardiac arrest, and hemorrhage. A technique called oscillatory lower body negative pressure (OLBNP) will be used in healthy human participants, facilitating delivery of blood flow to the brain with different pulsing patterns. This technique will allow for determination of the ideal pattern of brain blood flow that improves oxygenation of the brain tissue. Measurements will be made of substances in the blood that may be released with pulsatile flow which act on the blood vessels to increase flow and delivery of oxygen.

Conditions Studied

Hemorrhage

Interventions

  • OTHER 0 Hz Control
  • OTHER 0.1 Hz PPT
  • OTHER 0.05 Hz PPT

Study Locations (1)

Texas

  • University of North Texas Health Science Center - Fort Worth

Trial Details

FieldValue
Enrollment Target 21 participants
Start Date 2020-02-27
Est. Completion 2021-12-17
Phase NA

Sponsor

Caroline Rickards

1 total trials

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What the Registry Record Tells You About NCT05983744

The ClinicalTrials.gov registry entry for NCT05983744 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 266-participant average among 20 other Hemorrhage trials with a reported enrollment target (92% lower). The listed sponsor is Caroline Rickards, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Hemorrhage appearing as the primary indexed condition, and to 3 interventions - of which 0 Hz Control is the first listed.

NCT05983744 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT05983744 about?

NCT05983744 is a clinical study titled "Pulsatile Perfusion Therapy Phase II". Individuals who suffer from a stroke, cardiac arrest, or traumatic bleeding (hemorrhage) injuries often have compromised blood flow and oxygen to the brain which can lead to the death of brain cells, and if the patient survives, subsequent difficulty in thinking and performing tasks of daily living....

What is the current status of trial NCT05983744?

This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2020-02-27. Estimated completion is 2021-12-17.

What conditions does trial NCT05983744 study?

This clinical trial studies the following conditions: Hemorrhage.

What interventions are being tested in trial NCT05983744?

The interventions under investigation include: 0 Hz Control (OTHER), 0.1 Hz PPT (OTHER), 0.05 Hz PPT (OTHER).

Who is sponsoring clinical trial NCT05983744?

This trial is sponsored by Caroline Rickards, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05983744 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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