Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05912881 · ClinicalTrials.gov registry record · NA
Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery
A NA study of Anosmia and Skull Base Neoplasms, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 41
- Enrollment target
- 1
- Study location
NCT05912881: Completed NA study of Anosmia and Skull Base Neoplasms, sponsored by Johns Hopkins University.
NCT05912881 is a NA study of Anosmia and Skull Base Neoplasms that has completed, run by Johns Hopkins University. The registered enrollment target is 41 participants, below the 236-participant average among 5 other Anosmia trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05912881, a NA study of Anosmia and Skull Base Neoplasms, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.
Primary Outcome
Olfactory function as determined using the commercially available "Sniffin' Sticks" olfactory testing kit. Olfactory function is tested in three domains: threshold, discrimination, and identification. For threshold testing, the most dilute concentration of odorant that the participant is able to reliably detect is determined. In discrimination testing, the participant is evaluated on their ability to discern the unique scent among three scented sticks. In identification testing, the patient name
Conditions Studied
Interventions
- OTHER Olfactory training
- OTHER Placebo training
Study Locations (1)
Maryland
- Johns Hopkins Medicine - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2023-02-01 |
| Est. Completion | 2026-01-01 |
| Phase | NA |
What the finished NCT05912881 record still lists
NCT05912881 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 41 participants, a relatively small participant target, below the 236-participant average among 5 other Anosmia trials with a reported enrollment target (83% lower).
The record links to 2 conditions, with Anosmia appearing as the primary indexed condition, and to 2 interventions - of which Olfactory training is the first listed.
NCT05912881 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT05912881 about?
NCT05912881 is a clinical study titled "Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery". The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperativ...
What is the current status of trial NCT05912881?
This trial is currently completed. It is a NA study. The enrollment target is 41 participants. The study started on 2023-02-01. Estimated completion is 2026-01-01.
What conditions does trial NCT05912881 study?
This clinical trial studies the following conditions: Anosmia, Skull Base Neoplasms.
What interventions are being tested in trial NCT05912881?
The interventions under investigation include: Olfactory training (OTHER), Placebo training (OTHER).
Who is sponsoring clinical trial NCT05912881?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05912881 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anosmia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults
RECRUITING · NA
-
Investigating the Efficacy of OMT to Recover Olfactory Perception After COVID-19
RECRUITING · NA
-
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
ACTIVE NOT RECRUITING
-
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction
ACTIVE NOT RECRUITING · Phase 2
-
Smell Changes & Efficacy of Nasal Theophylline
COMPLETED · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03449238 · 41 participants · Phase 1
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
- NCT03900793 · 41 participants · Phase 1
Losartan + Sunitinib in Treatment of Osteosarcoma
- NCT04082520 · 41 participants · Phase 2
Lutathera for the Treatment of Inoperable, Progressive Meningioma After External Beam Radiation Therapy
- NCT04220190 · 41 participants · Phase 2
RAPA-501 Therapy for ALS
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI