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ACTIVE NOT RECRUITING NA

REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)

NCT05652218 · View on ClinicalTrials.gov ↗

Study Summary

Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide levels among patients with symptomatic HF, LVEF \> 35%, and LBBB.

Interventions

  • DEVICE LB-CRT
  • DEVICE BIV-CRT

Study Locations (2)

North Carolina

  • Duke University Medical Center — Durham

Virginia

  • Inova Health System — Falls Church

Trial Details

FieldValue
Enrollment Target 21 participants
Start Date 2023-02-26
Est. Completion 2026-03-31
Phase NA

Sponsor

Inova Health Care Services

56 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05652218

The ClinicalTrials.gov registry entry for NCT05652218 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Inova Health Care Services, which has 56 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Heart Failure (HF) appearing as the primary indexed condition, and to 2 interventions — of which LB-CRT is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05652218 reports 2 study locations spanning 2 distinct geographic areas — top geographies include North Carolina, Virginia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05652218 about?

NCT05652218 is a clinical study titled "REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)". Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide levels among patients with symptomatic HF, LVEF \> 35%, and LBBB.

What is the current status of trial NCT05652218?

This trial is currently active not recruiting. It is a NA study. The enrollment target is 21 participants. The study started on 2023-02-26. Estimated completion is 2026-03-31.

What conditions does trial NCT05652218 study?

This clinical trial studies the following conditions: Heart Failure (HF), Left Bundle-Branch Block, Left Ventricular Ejection Fraction. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05652218?

The interventions under investigation include: LB-CRT (DEVICE), BIV-CRT (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05652218?

This trial is sponsored by Inova Health Care Services, which has 56 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05652218 being conducted?

This trial has 2 study locations across North Carolina, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial