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NCT05651932 · ClinicalTrials.gov registry record · Phase 1
A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma
A Phase 1 study of Multiple Myeloma and Myeloma, sponsored by K36 Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 125
- Enrollment target
- 20
- Study locations
NCT05651932 is a Phase 1 study of Multiple Myeloma and Myeloma that is actively recruiting participants, run by K36 Therapeutics. The registered enrollment target is 125 participants, below the 546-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (77% lower). The trial reports 20 study locations across 15 states.
The verdict
NCT05651932, a Phase 1 study of Multiple Myeloma and Myeloma, is actively recruiting participants, sponsored by K36 Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 125 participants
- Enrollment target
- 20
- Study locations
Study Summary
A Phase I study to evaluate the safety of a novel, orally available, selective, and potent small molecule inhibitor of the histone lysine methyl transferase MMSET (also known as NSD2/WHSC1) to prevent the dimethylation of H3K36 in adult patients with relapsed or refractory multiple myeloma (RRMM).
Conditions Studied
Interventions
- DRUG Cohort A1 & A2: KTX-1001
- DRUG Cohort B1 & B2: KTX-1001+Mezigdomide
- DRUG Cohort C1 & C2: KTX-1001 + Carfilzomib (KYPROLIS®)
- DRUG Cohort D: KTX-1001+ pomalidomide (Pomalyst, Imnovid)
Study Locations (20)
Other
- Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu - Nantes
- Centre Hospitalier Universitaire de Poitiers (CHU de Poitiers) - Poitiers
- Institut Universitaire du Cancer de Toulouse - Oncopole - Toulouse
- Hospital ClÃ-nic de Barcelona - Barcelona
Massachusetts
- Massachusetts General Hospital - Boston
- Dana-Farber Cancer Institute - Boston
North Carolina
- Atrium Health, Levine Cancer Institute - Charlotte
- Duke University Hospital - Durham
California
- UCSF Medical Center - Hematology and Blood and Marrow Transplant Clinic - San Francisco
Florida
- Mayo Clinic Hospital - Florida - Jacksonville
Georgia
- The Winship Cancer Institute of Emory University - Atlanta
Minnesota
- Mayo Clinic - Transplant Center - Rochester - Rochester
New Jersey
- Hackensack University Medical Center - Hackensack
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 125 participants |
| Start Date | 2023-02-22 |
| Est. Completion | 2028-06-30 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05651932
The ClinicalTrials.gov registry entry for NCT05651932 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 125 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 546-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (77% lower). The listed sponsor is K36 Therapeutics, which has 2 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions - of which Cohort A1 & A2: KTX-1001 is the first listed.
NCT05651932 reports 20 study locations spanning 15 distinct geographic areas - top geographies include Other, Massachusetts, North Carolina.
Frequently Asked Questions
What is clinical trial NCT05651932 about?
NCT05651932 is a clinical study titled "A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma". A Phase I study to evaluate the safety of a novel, orally available, selective, and potent small molecule inhibitor of the histone lysine methyl transferase MMSET (also known as NSD2/WHSC1) to prevent the dimethylation of H3K36 in adult patients with relapsed or refractory multiple myeloma (RRMM).
What is the current status of trial NCT05651932?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 125 participants. The study started on 2023-02-22. Estimated completion is 2028-06-30.
What conditions does trial NCT05651932 study?
This clinical trial studies the following conditions: Multiple Myeloma, Myeloma, Myeloma Multiple.
What interventions are being tested in trial NCT05651932?
The interventions under investigation include: Cohort A1 & A2: KTX-1001 (DRUG), Cohort B1 & B2: KTX-1001+Mezigdomide (DRUG), Cohort C1 & C2: KTX-1001 + Carfilzomib (KYPROLIS®) (DRUG), Cohort D: KTX-1001+ pomalidomide (Pomalyst, Imnovid) (DRUG).
Who is sponsoring clinical trial NCT05651932?
This trial is sponsored by K36 Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05651932 being conducted?
This trial has 20 study locations across California, Florida, Georgia, Massachusetts, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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