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RECRUITING Phase 1

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

NCT05651932 · View on ClinicalTrials.gov ↗

Study Summary

A Phase I study to evaluate the safety of a novel, orally available, selective, and potent small molecule inhibitor of the histone lysine methyl transferase MMSET (also known as NSD2/WHSC1) to prevent the dimethylation of H3K36 in adult patients with relapsed or refractory multiple myeloma (RRMM).

Interventions

  • DRUG Cohort A1 & A2: KTX-1001
  • DRUG Cohort B1 & B2: KTX-1001+Mezigdomide
  • DRUG Cohort C1 & C2: KTX-1001 + Carfilzomib (KYPROLIS®)
  • DRUG Cohort D: KTX-1001+ pomalidomide (Pomalyst, Imnovid)

Study Locations (20)

Other

  • Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu — Nantes
  • Centre Hospitalier Universitaire de Poitiers (CHU de Poitiers) — Poitiers
  • Institut Universitaire du Cancer de Toulouse - Oncopole — Toulouse
  • Hospital ClÃ-nic de Barcelona — Barcelona

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana-Farber Cancer Institute — Boston

North Carolina

  • Atrium Health, Levine Cancer Institute — Charlotte
  • Duke University Hospital — Durham

California

  • UCSF Medical Center - Hematology and Blood and Marrow Transplant Clinic — San Francisco

Florida

  • Mayo Clinic Hospital - Florida — Jacksonville

Georgia

  • The Winship Cancer Institute of Emory University — Atlanta

Minnesota

  • Mayo Clinic - Transplant Center - Rochester — Rochester

New Jersey

  • Hackensack University Medical Center — Hackensack

Trial Details

FieldValue
Enrollment Target 125 participants
Start Date 2023-02-22
Est. Completion 2028-06-30
Phase Phase 1

Sponsor

K36 Therapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05651932

The ClinicalTrials.gov registry entry for NCT05651932 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 125 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is K36 Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions — of which Cohort A1 & A2: KTX-1001 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05651932 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Other, Massachusetts, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05651932 about?

NCT05651932 is a clinical study titled "A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma". A Phase I study to evaluate the safety of a novel, orally available, selective, and potent small molecule inhibitor of the histone lysine methyl transferase MMSET (also known as NSD2/WHSC1) to prevent the dimethylation of H3K36 in adult patients with relapsed or refractory multiple myeloma (RRMM).

What is the current status of trial NCT05651932?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 125 participants. The study started on 2023-02-22. Estimated completion is 2028-06-30.

What conditions does trial NCT05651932 study?

This clinical trial studies the following conditions: Multiple Myeloma, Myeloma, Myeloma Multiple. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05651932?

The interventions under investigation include: Cohort A1 & A2: KTX-1001 (DRUG), Cohort B1 & B2: KTX-1001+Mezigdomide (DRUG), Cohort C1 & C2: KTX-1001 + Carfilzomib (KYPROLIS®) (DRUG), Cohort D: KTX-1001+ pomalidomide (Pomalyst, Imnovid) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05651932?

This trial is sponsored by K36 Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05651932 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Massachusetts, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial