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COMPLETED Phase 1

Evaluation of OLX10212 in Patients With Neovascular Age-related Macular Degeneration

NCT05643118 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 1, multicenter, open-label, single- and multi-dose, dose-escalating study of OLX10212 in patients with neovascular age-related macular degeneration (AMD). This study is composed of 2 parts: Part A and Part B. Part A is a single ascending dose study, and Part B is a multiple ascending dose study. The primary objective is to evaluate the safety and tolerability of single and multiple intravitreal injection(s) of OLX10212 in patients with neovascular AMD. The exploratory objectives are to evaluate the preliminary efficacy of single and multiple intravitreal injection(s) of OLX10212 in patients with neovascular AMD, and to evaluate the pharmacokinetics (PK) of single and multiple intravitreal injection(s) of OLX10212 in patients with neovascular AMD.

Interventions

  • GENETIC OLX10212 is a cell penetrating asymmetric small interference RNA (cp-asiRNA)

Study Locations (5)

California

  • California Retina Consultants — Santa Maria

Illinois

  • University Retina — Oak Forest

Missouri

  • The Retina Institute — St Louis

New York

  • Ophthalmic Consultants of the Capital Region — Troy

Texas

  • Texas Retina Consultants — Bellaire

Trial Details

FieldValue
Enrollment Target 21 participants
Start Date 2023-01-04
Est. Completion 2025-11-10
Phase Phase 1

Sponsor

Olix Pharmaceuticals

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05643118

The ClinicalTrials.gov registry entry for NCT05643118 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Olix Pharmaceuticals, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Neovascular Age-related Macular Degeneration appearing as the primary indexed condition, and to 1 intervention — of which OLX10212 is a cell penetrating asymmetric small interference RNA (cp-asiRNA) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05643118 reports 5 study locations spanning 5 distinct geographic areas — top geographies include California, Illinois, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05643118 about?

NCT05643118 is a clinical study titled "Evaluation of OLX10212 in Patients With Neovascular Age-related Macular Degeneration". This is a Phase 1, multicenter, open-label, single- and multi-dose, dose-escalating study of OLX10212 in patients with neovascular age-related macular degeneration (AMD). This study is composed of 2 parts: Part A and Part B. Part A is a single ascending dose study, and Part B is a multiple ascending...

What is the current status of trial NCT05643118?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 21 participants. The study started on 2023-01-04. Estimated completion is 2025-11-10.

What conditions does trial NCT05643118 study?

This clinical trial studies the following conditions: Neovascular Age-related Macular Degeneration. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05643118?

The interventions under investigation include: OLX10212 is a cell penetrating asymmetric small interference RNA (cp-asiRNA) (GENETIC). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05643118?

This trial is sponsored by Olix Pharmaceuticals, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05643118 being conducted?

This trial has 5 study locations across California, Illinois, Missouri, New York, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial