Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study Evaluating UCART20x22 in B-Cell Non-Hodgkin Lymphoma
NCT05607420 · View on ClinicalTrials.gov ↗
Study Summary
First-in-human, open-label, dose-finding and dose-expansion study of UCART20x22 administered intravenously in subjects with relapsed or refractory B-Cell Non-Hodgkin Lymphoma (B-NHL). The purpose of this study is to evaluate the safety and clinical activity of UCART20x22 and determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D).
Conditions Studied
Interventions
- BIOLOGICAL CLLS52
- BIOLOGICAL UCART20x22
Study Locations (10)
Other
- Centre Hospitalier Universitaire de Nantes (CHU de Nantes)-Hotel-Dieu — Nantes
- Hospital Universitario Virgen del Rocio (HUVR) - Instituto de Biomedicina de Sevilla (IBIS) — Seville
Illinois
- The University of Chicago Medical Center (UCMC) — Chicago
Massachusetts
- Harvard Medical School - Massachusetts General Hospital — Boston
New Jersey
- Rutgers Cancer Institute of New Jersey (CINJ) - New Brunswick — New Brunswick
Texas
- Sarah Cannon - St. David South Austin Medical Center — Austin
Auvergne Rhone Alpe
- Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud — Pierre-Bénite
Occitanie
- Centre Hospitalier Universitaire de Montpellier (CHU Montpellier) - Hopital Saint-Eloi — Montpellier
Île-de-France Region
- Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Saint-Louis - Centre Integre en Cancerologie — Paris
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2022-11-01 |
| Est. Completion | 2027-08 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05607420
The ClinicalTrials.gov registry entry for NCT05607420 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Cellectis S.A., which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with B-cell Non-Hodgkin Lymphoma (B-NHL) appearing as the primary indexed condition, and to 2 interventions — of which CLLS52 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05607420 reports 10 study locations spanning 9 distinct geographic areas — top geographies include Other, Illinois, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05607420 about?
NCT05607420 is a clinical study titled "Study Evaluating UCART20x22 in B-Cell Non-Hodgkin Lymphoma". First-in-human, open-label, dose-finding and dose-expansion study of UCART20x22 administered intravenously in subjects with relapsed or refractory B-Cell Non-Hodgkin Lymphoma (B-NHL). The purpose of this study is to evaluate the safety and clinical activity of UCART20x22 and determine the Maximum To...
What is the current status of trial NCT05607420?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 80 participants. The study started on 2022-11-01. Estimated completion is 2027-08.
What conditions does trial NCT05607420 study?
This clinical trial studies the following conditions: B-cell Non-Hodgkin Lymphoma (B-NHL). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05607420?
The interventions under investigation include: CLLS52 (BIOLOGICAL), UCART20x22 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05607420?
This trial is sponsored by Cellectis S.A., which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05607420 being conducted?
This trial has 10 study locations across Illinois, Massachusetts, New Jersey, Texas, Auvergne Rhone Alpe. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.