Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 1

A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma

NCT05535244 · View on ClinicalTrials.gov ↗

Study Summary

This study will evaluate the efficacy, safety, and pharmacokinetics of cevostamab in participants with relapsed or refractory multiple myeloma (R/R MM) via intravenous (IV) infusion.

Conditions Studied

Interventions

  • DRUG Tocilizumab
  • DRUG Cevostamab

Study Locations (20)

Other

  • UZ Leuven Gasthuisberg — Leuven
  • CHU NANTES - Hôtel Dieu — Nantes
  • APHP - Hospital Saint Louis — Paris
  • CHU de Poitiers - La Miletrie — Poitiers
  • Klinik der Uni zu Köln — Cologne
  • Universitätsklinikum Hamburg-Eppendorf Onkologisches Zentrum Medizinische Klinik II — Hamburg
  • Universitätsklinikum Würzburg — Würzburg
  • Hadassah Ein Karem Hospital — Jerusalem
  • Sheba Medical Center — Ramat Gan
  • Sourasky Medical Centre — Tel Aviv

Colorado

  • University of Colorado — Aurora

Florida

  • Mayo Clinic-Jacksonville — Jacksonville

Maryland

  • University of Maryland Greenebaum Cancer Center — Baltimore

Massachusetts

  • Dana Farber Cancer Institute — Boston

Minnesota

  • Mayo Clinic - Rochester — Rochester

New York

  • Memorial Sloan Kettering Cancer Center — New York

Tennessee

  • Tennessee Oncology - Nashville — Nashville

Trial Details

FieldValue
Enrollment Target 90 participants
Start Date 2022-10-17
Est. Completion 2027-02-26
Phase Phase 1

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05535244

The ClinicalTrials.gov registry entry for NCT05535244 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions — of which Tocilizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05535244 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Other, Colorado, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05535244 about?

NCT05535244 is a clinical study titled "A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma". This study will evaluate the efficacy, safety, and pharmacokinetics of cevostamab in participants with relapsed or refractory multiple myeloma (R/R MM) via intravenous (IV) infusion.

What is the current status of trial NCT05535244?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 90 participants. The study started on 2022-10-17. Estimated completion is 2027-02-26.

What conditions does trial NCT05535244 study?

This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05535244?

The interventions under investigation include: Tocilizumab (DRUG), Cevostamab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05535244?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05535244 being conducted?

This trial has 20 study locations across Colorado, Florida, Maryland, Massachusetts, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial