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NCT05439460 · ClinicalTrials.gov registry record · Phase 4
Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension
A Phase 4 study, sponsored by Stanford University.
- Completed
- Registry status
- Phase 4
- Development phase
- 15
- Enrollment target
NCT05439460: Completed Phase 4 study, sponsored by Stanford University.
NCT05439460 is a Phase 4 study that has completed, run by Stanford University. The registered enrollment target is 15 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05439460, a Phase 4 study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 15 participants
- Enrollment target
Study Summary
Pulmonary arterial hypertension (PAH) is a disease where the blood pressure in the pulmonary arteries (PAP) is high. PAH increases the risk of adverse events, including death, during and or after procedures. The severity of baseline PAH correlates with the incidence of major complications, such that those with PAP higher than their systemic blood pressure (SBP) had a 8 fold increased risk of complications. These children present for procedures where an acute exacerbation of their chronic illness-termed Pulmonary Hypertensive (PH)crisis, can occur, often resulting in death if not detected and managed expeditiously. Unfortunately there is little data and no consensus in the pediatric literature on how PH crisis should be managed. \--------------------------------------------------------------------------------
Primary Outcome
In patients with pulmonary hypertension (PH) one anticipates a greater increase in pulmonary vascular resistance as opposed to systemic vascular resistance when vasopressors are administered.
Interventions
- DRUG Epinephrine
- DRUG Phenylephrine
- DRUG Arginine Vasopressin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2012-01 |
| Est. Completion | 2014-06 |
| Phase | Phase 4 |
What the finished NCT05439460 record still lists
NCT05439460 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 3 interventions - of which Epinephrine is the first listed.
NCT05439460 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05439460 about?
NCT05439460 is a clinical study titled "Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension". Pulmonary arterial hypertension (PAH) is a disease where the blood pressure in the pulmonary arteries (PAP) is high. PAH increases the risk of adverse events, including death, during and or after procedures. The severity of baseline PAH correlates with the incidence of major complications, such that...
What is the current status of trial NCT05439460?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 15 participants. The study started on 2012-01. Estimated completion is 2014-06.
What interventions are being tested in trial NCT05439460?
The interventions under investigation include: Epinephrine (DRUG), Phenylephrine (DRUG), Arginine Vasopressin (DRUG).
Who is sponsoring clinical trial NCT05439460?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05439460's enrollment target sits among peer trials
15 1880th of 2000 higher than 100 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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