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Prehospital Analgesia INtervention Trial (PAIN)
NCT05437575 · View on ClinicalTrials.gov ↗
Study Summary
The Prehospital Analgesia INtervention trial (PAIN) is a proposed 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial that will enroll approximately 994 patients at select LITES Network sites. The objective is to perform a prospective, interventional, randomized trial among prehospital trauma patients with compensated shock (SI≥0.9 or HR ≥115) and an indication for pain management, comparing patient centered outcomes following prehospital administration of ketamine hydrochloride versus fentanyl citrate.
Conditions Studied
Interventions
- DRUG Ketamine Hydrochloride
- DRUG Fentanyl Citrate
Study Locations (11)
Pennsylvania
- Allegheny Health Network (AHN) Allegheny General Hospital — Pittsburgh
- University of Pittsburgh — Pittsburgh
- Guthrie Robert Packer Hospital — Sayre
California
- University of California, San Diego — San Diego
- Zuckerberg San Francisco General Hospital — San Francisco
New Jersey
- Cooper University Health Care — Camden
North Carolina
- Atrium Health and Carolinas Medical Center — Charlotte
Ohio
- University of Cincinnati — Cincinnati
Utah
- University of Utah — Salt Lake City
Vermont
- The University of Vermont Larner College of Medicine — Burlington
Wisconsin
- Medical College of Wisconsin — Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 994 participants |
| Start Date | 2023-11-27 |
| Est. Completion | 2029-07 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05437575
The ClinicalTrials.gov registry entry for NCT05437575 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 994 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Jason Sperry, which has 33 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Traumatic Injury appearing as the primary indexed condition, and to 2 interventions — of which Ketamine Hydrochloride is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05437575 reports 11 study locations spanning 8 distinct geographic areas — top geographies include Pennsylvania, California, New Jersey. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05437575 about?
NCT05437575 is a clinical study titled "Prehospital Analgesia INtervention Trial (PAIN)". The Prehospital Analgesia INtervention trial (PAIN) is a proposed 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial that will enroll approximately 994 patients at select LITES Network sites. The objective is to perform a prospective, interventional, random...
What is the current status of trial NCT05437575?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 994 participants. The study started on 2023-11-27. Estimated completion is 2029-07.
What conditions does trial NCT05437575 study?
This clinical trial studies the following conditions: Traumatic Injury. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05437575?
The interventions under investigation include: Ketamine Hydrochloride (DRUG), Fentanyl Citrate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05437575?
This trial is sponsored by Jason Sperry, which has 33 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05437575 being conducted?
This trial has 11 study locations across California, New Jersey, North Carolina, Ohio, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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