Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05406362 · ClinicalTrials.gov registry record · Phase 1
Assess Safety and Efficacy of VAD044 in HHT Patients
A Phase 1 study of Hereditary Hemorrhagic Telangiectasia (HHT), sponsored by Vaderis Therapeutics.
- Active
- Registry status
- Phase 1
- Development phase
- 75
- Enrollment target
- 7
- Study locations
NCT05406362 is a Phase 1 study of Hereditary Hemorrhagic Telangiectasia (HHT) that is active but no longer recruiting, run by Vaderis Therapeutics. The registered enrollment target is 75 participants, above the 61-participant average among 3 other Hereditary Hemorrhagic Telangiectasia (HHT) trials with a reported enrollment target (23% higher). The trial reports 7 study locations across 2 states.
The verdict
NCT05406362, a Phase 1 study of Hereditary Hemorrhagic Telangiectasia (HHT), is active but no longer recruiting, sponsored by Vaderis Therapeutics.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 75 participants
- Enrollment target
- 7
- Study locations
Study Summary
Part I: The purpose of this Phase 1b proof of concept study, randomised, placebo controlled, double blind, multicentre study is to asssess safety and efficacy of 2 doses of VAD044 in adult HHT patients. Part II: The purpose of this open-label extension following the completion of the randomised double blind treatment and follow-up period (Part I of the study) is to assess the long-term safetty, tolerability and efficacy of VAD044 in adult HHT patients.
Conditions Studied
Interventions
- DRUG VAD044 Part I
- DRUG VAD044 Part II
Study Locations (7)
Other
- Universitair Ziekenhuis Gent - Ghent
- Hospices Civils de Lyon - Lyon
- Ospedale Maggiore di Crema - Crema
- St. Antonius Hospital - Nieuwegein
- Hospital Universiati De Bellvitge - Barcelona
- Hospital Universitario Ramón y Cajal - Madrid
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2022-07-18 |
| Est. Completion | 2027-01 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05406362
The ClinicalTrials.gov registry entry for NCT05406362 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 75 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 61-participant average among 3 other Hereditary Hemorrhagic Telangiectasia (HHT) trials with a reported enrollment target (23% higher). The listed sponsor is Vaderis Therapeutics, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Hereditary Hemorrhagic Telangiectasia (HHT) appearing as the primary indexed condition, and to 2 interventions - of which VAD044 Part I is the first listed.
NCT05406362 reports 7 study locations spanning 2 distinct geographic areas - top geographies include Other, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05406362 about?
NCT05406362 is a clinical study titled "Assess Safety and Efficacy of VAD044 in HHT Patients". Part I: The purpose of this Phase 1b proof of concept study, randomised, placebo controlled, double blind, multicentre study is to asssess safety and efficacy of 2 doses of VAD044 in adult HHT patients. Part II: The purpose of this open-label extension following the completion of the randomised dou...
What is the current status of trial NCT05406362?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 75 participants. The study started on 2022-07-18. Estimated completion is 2027-01.
What conditions does trial NCT05406362 study?
This clinical trial studies the following conditions: Hereditary Hemorrhagic Telangiectasia (HHT).
What interventions are being tested in trial NCT05406362?
The interventions under investigation include: VAD044 Part I (DRUG), VAD044 Part II (DRUG).
Who is sponsoring clinical trial NCT05406362?
This trial is sponsored by Vaderis Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05406362 being conducted?
This trial has 7 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hereditary Hemorrhagic Telangiectasia (HHT)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.