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A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
NCT05372354 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).
Conditions Studied
Interventions
- DRUG Dexamethasone
- DRUG Trametinib
- DRUG Tazemetostat
- DRUG CC-92480
- DRUG BMS-986158
Study Locations (17)
Other
- ICO - Hospital Germans Trias i Pujol — Barcelona
- Hospital Universitario 12 de Octubre — Madrid
- Hospital Universitario Marques de Valdecilla — Santander
- NIHR UCLH Clinical Research Facility — London
Alberta
- Alberta Health Services AHS - Foothills Medical Centre FMC — Calgary
- University of Alberta - Cross Cancer Institute — Edmonton
Alabama
- UAB Comprehensive Cancer Center — Birmingham
Maryland
- Johns Hopkins Medicine - The Sidney Kimmel Comprehensive Cancer Center — Baltimore
Massachusetts
- Dana-Farber Cancer Institute — Boston
New Jersey
- John Theurer Cancer Center at Hackensack UMC — Hackensack
New York
- Memorial Sloan Kettering Cancer Center — New York
Ontario
- University Health Network UHN - Princess Margaret Hospital PMH — Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 260 participants |
| Start Date | 2022-10-18 |
| Est. Completion | 2026-10-12 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05372354
The ClinicalTrials.gov registry entry for NCT05372354 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 260 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Dexamethasone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05372354 reports 17 study locations spanning 13 distinct geographic areas — top geographies include Other, Alberta, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05372354 about?
NCT05372354 is a clinical study titled "A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma". The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).
What is the current status of trial NCT05372354?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 260 participants. The study started on 2022-10-18. Estimated completion is 2026-10-12.
What conditions does trial NCT05372354 study?
This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05372354?
The interventions under investigation include: Dexamethasone (DRUG), Trametinib (DRUG), Tazemetostat (DRUG), CC-92480 (DRUG), BMS-986158 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05372354?
This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05372354 being conducted?
This trial has 17 study locations across Alabama, Maryland, Massachusetts, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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