Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer
NCT05128825 · View on ClinicalTrials.gov ↗
Study Summary
This is a multi-part Phase 2 study to evaluate the efficacy and safety of azenosertib (ZN-c3) in subjects with Platinum-Resistant, High-Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer. Part 2 of the study will be conducted in subjects whose tumors are Cyclin E1 positive as determined by central review using the Sponsor's investigational clinical trial assay.
Conditions Studied
Interventions
- DRUG azenosertib
Study Locations (20)
Florida
- Site 0239 - Florida Cancer Specialists - East — Daytona Beach
- Site 0173 - Mount Sinai Medical Center — Miami Beach
- Site 0308 - Advent Health — Orlando
Massachusetts
- Site 0221 - Tufts Medical Center - PPDS — Boston
- Site 0104 - Dana Farber Cancer Institute — Boston
- Site 0307 - Lahey Hospital and Medical Center — Burlington
Arizona
- Site 0143 - HonorHealth — Phoenix
- Site 0102 - University of Arizona Cancer Center — Tucson
California
- Site 0258 - UC San Diego Moores Cancer Center — La Jolla
- Site 0287 - Ridley Tree Cancer Center — Santa Barbara
Georgia
- Site 0108 - Emory University Hospital — Atlanta
- Site 0236 - Memorial Health — Savannah
Indiana
- Site 0284 - Community Cancer Center North — Indianapolis
- Site 0217 - St Vincent Hospital and Health Care Centers — Indianapolis
Alabama
- Site 0170-USA Mitchell Cancer Institute — Mobile
Colorado
- Site 0135 - Rocky Mountain Cancer Centers — Lone Tree
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 170 participants |
| Start Date | 2022-02-17 |
| Est. Completion | 2027-06-30 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05128825
The ClinicalTrials.gov registry entry for NCT05128825 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 170 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer appearing as the primary indexed condition, and to 1 intervention — of which azenosertib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05128825 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Florida, Massachusetts, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05128825 about?
NCT05128825 is a clinical study titled "A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer". This is a multi-part Phase 2 study to evaluate the efficacy and safety of azenosertib (ZN-c3) in subjects with Platinum-Resistant, High-Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer. Part 2 of the study will be conducted in subjects whose tumors are Cyclin E1 positive as determi...
What is the current status of trial NCT05128825?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 170 participants. The study started on 2022-02-17. Estimated completion is 2027-06-30.
What conditions does trial NCT05128825 study?
This clinical trial studies the following conditions: High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05128825?
The interventions under investigation include: azenosertib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05128825?
This trial is sponsored by K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05128825 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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