Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 2

A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease

NCT04987489 · View on ClinicalTrials.gov ↗

Study Summary

This clinical trial is a Phase 2 study that will evaluate the safety and clinical activity of etavopivat in patients with thalassemia or sickle cell disease and test how well etavopivat works to lower the number of red blood cell transfusions required and increase hemoglobin.

Interventions

  • DRUG Etavopivat tablets

Study Locations (20)

California

  • TOI Clinical Research — Cerritos
  • [Legal] Children's Hospital Los Angeles — Los Angeles
  • University of Californ LA-UCLA — Los Angeles
  • UCSF Oakland Benioff ChildHosp — Oakland
  • [Legal] Children's Hospital of Orange County on behalf of CHOC Children's Hospital of Orange County — Orange
  • UCI Health — Orange

Ontario

  • Master Centre for Canada — Mississauga
  • The Hospital for Sick Children — Toronto
  • University Health Network - Toronto General Hospital — Toronto

North Carolina

  • Duke University — Durham
  • East Carolina University — Greenville

Other

  • Cairo University — Cairo
  • Abu El-Reesh El-Mounira Children University Hospital — Cairo, Egypt

District of Columbia

  • Children's National Health Hospital — Washington D.C.

Georgia

  • Children's Hospital of Atlanta — Atlanta

Michigan

  • [Legal] Dr. Vince Clinical Research, LLC and Dr. Vince Clinical Research, P.A. — Detroit

New York

  • Weill Medical College of Cornell University — New York

Trial Details

FieldValue
Enrollment Target 53 participants
Start Date 2022-03-28
Est. Completion 2025-09-24
Phase Phase 2

Sponsor

Forma Therapeutics

2 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04987489

The ClinicalTrials.gov registry entry for NCT04987489 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 53 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Forma Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Sickle Cell Disease appearing as the primary indexed condition, and to 1 intervention — of which Etavopivat tablets is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04987489 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Ontario, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04987489 about?

NCT04987489 is a clinical study titled "A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease". This clinical trial is a Phase 2 study that will evaluate the safety and clinical activity of etavopivat in patients with thalassemia or sickle cell disease and test how well etavopivat works to lower the number of red blood cell transfusions required and increase hemoglobin.

What is the current status of trial NCT04987489?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 53 participants. The study started on 2022-03-28. Estimated completion is 2025-09-24.

What conditions does trial NCT04987489 study?

This clinical trial studies the following conditions: Sickle Cell Disease, Thalassemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04987489?

The interventions under investigation include: Etavopivat tablets (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04987489?

This trial is sponsored by Forma Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04987489 being conducted?

This trial has 20 study locations across California, District of Columbia, Georgia, Michigan, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial