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Dose Escalation and Dose Expansion Study of CPO-100 in Patients With Advanced Solid Tumors
NCT04931823 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 1, multicenter, open-label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary evidence of antitumor activity of CPO-100 administered intravenously in cycles of 3 weekly doses with 1 week rest (1 cycle = 4 weeks) in adult patients with advanced solid tumors.
Conditions Studied
Interventions
- DRUG CPO-100
Study Locations (8)
California
- University of California Los Angeles — Los Angeles
Connecticut
- Yale University School of Medicine - Yale Cancer Center — New Haven
Nevada
- Comprehensive Cancer Centers of Nevada — Las Vegas
North Carolina
- Carolina BioOncology Institute — Huntersville
Ohio
- The Cleveland Clinic Foundation — Lyndhurst
Pennsylvania
- University of Pittsburgh Medical Center — Pittsburgh
Texas
- Texas Oncology - Baylor Charles A. Sammons Cancer Center — Dallas
Virginia
- Virginia Cancer Specialist — Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2021-03-24 |
| Est. Completion | 2025-03-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04931823
The ClinicalTrials.gov registry entry for NCT04931823 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 126 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Conjupro Biotherapeutics, which has 35 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Solid Tumor appearing as the primary indexed condition, and to 1 intervention — of which CPO-100 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04931823 reports 8 study locations spanning 8 distinct geographic areas — top geographies include California, Connecticut, Nevada. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04931823 about?
NCT04931823 is a clinical study titled "Dose Escalation and Dose Expansion Study of CPO-100 in Patients With Advanced Solid Tumors". This is a Phase 1, multicenter, open-label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary evidence of antitumor activity of CPO-100 administered intravenously in cycles of 3 weekly doses with 1 week rest (1 cycle = 4 weeks) in adult ...
What is the current status of trial NCT04931823?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 126 participants. The study started on 2021-03-24. Estimated completion is 2025-03-01.
What conditions does trial NCT04931823 study?
This clinical trial studies the following conditions: Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04931823?
The interventions under investigation include: CPO-100 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04931823?
This trial is sponsored by Conjupro Biotherapeutics, which has 35 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04931823 being conducted?
This trial has 8 study locations across California, Connecticut, Nevada, North Carolina, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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