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Vfib by ECG or Echo During Cardiac Arrest
NCT04906252 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this study is to measure survival rates associated with patients presenting in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm. Electrocardiographic rhythm is defined as the rhythm on the ECG and echocardiographic rhythm is the rhythm visualized on bedside ultrasound. Specifically, we will categorize patients based on identical rhythms and dichotomous rhythms with an interest in outcomes in the patient group where their echocardiographic and electrographic rhythms do not match. This is important as current ACLS protocols use electrocardiographic rhythms to determine therapy but limited research implies that therapeutic decisions based on echocardiographic rhythm may produce increased survival. This study will occur during emergency department resuscitation of patients presenting in cardiac arrest. Patients presenting to the emergency department after cardiac arrest will undergo standard resuscitation based on ACLS protocols. Ultrasound imaging will be performed as soon as possible after the patient arrives and digitally recorded, as is currently the standard of care at the institute. Simultaneous recording of the ECG rhythm strip will occur as well. This will be repeated for as many pauses in CPR as is warranted. Each site will record data based on the Utstein nomenclature including patient demographics, arrest details and survival outcomes. Ultrasound images and ECG recordings will be de-identified and submitted to a central database. Data will be uploaded into a centralized database. Statistical analysis will analyze outcomes based on echocardiographic and sonographic findings. Our aim is to measure the survival benefit of treating out of hospital cardiac arrest using echocardiographic rhythm instead of electrocardiographic rhythm.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Echocardiography
- DIAGNOSTIC_TEST Electrocardiogram (ECG)
Study Locations (6)
Connecticut
- Hartford Hospital — Hartford
New Hampshire
- Dartmouth Hitchcock Medical Center — Lebanon
New York
- Stony Brook University — Stony Brook
North Carolina
- Duke University — Durham
Pennsylvania
- Allegheny Hospital — Pittsburgh
Texas
- Univesity of Texas San Antonio — San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 813 participants |
| Start Date | 2021-09-15 |
| Est. Completion | 2025-01-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04906252
The ClinicalTrials.gov registry entry for NCT04906252 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 813 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Romolo Gaspari, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Cardiac Arrest appearing as the primary indexed condition, and to 2 interventions — of which Echocardiography is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04906252 reports 6 study locations spanning 6 distinct geographic areas — top geographies include Connecticut, New Hampshire, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04906252 about?
NCT04906252 is a clinical study titled "Vfib by ECG or Echo During Cardiac Arrest". The goal of this study is to measure survival rates associated with patients presenting in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm. Electrocardiographic rhythm is defined as the rhythm on the ECG and echocardiographic rhythm is the rhythm visualiz...
What is the current status of trial NCT04906252?
This trial is currently completed. The enrollment target is 813 participants. The study started on 2021-09-15. Estimated completion is 2025-01-01.
What conditions does trial NCT04906252 study?
This clinical trial studies the following conditions: Cardiac Arrest. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04906252?
The interventions under investigation include: Echocardiography (DIAGNOSTIC_TEST), Electrocardiogram (ECG) (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04906252?
This trial is sponsored by Romolo Gaspari, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04906252 being conducted?
This trial has 6 study locations across Connecticut, New Hampshire, New York, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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