Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Pembrolizumab (MK-3475) in Relapsed or Refractory Classical Hodgkin's Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL) (MK-3475-B68)
NCT04875195 · View on ClinicalTrials.gov ↗
Study Summary
The primary objective of the study is to evaluate the objective response rate (ORR), by cohort, rrcHL and rrPMBCL, as assessed by the investigator according to Lugano classification criteria 2014 in participants treated with pembrolizumab every six weeks (Q6W).
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
Study Locations (20)
Other
- Fakultni nemocnice Hradec Kralove-IV. interni hematologicka klinika ( Site 0304) — Hradec Králové
- Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0503) — Naples
Moscow
- The National Medico-Surgical Center N.I. Pirogov ( Site 0801) — Moscow
- Moscow City Clinical Hospital S.P. Botkin ( Site 0803) — Moscow
California
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site — Torrance
Louisiana
- Tulane Medical Center ( Site 0110) — New Orleans
Maryland
- Anne Arundel Medical Center-Anne Arundel Oncology and Hematology ( Site 0125) — Annapolis
Paraná
- Hospital Erasto Gaertner ( Site 1703) — Curitiba
São Paulo
- Fundação Pio XII - Hospital de Câncer de Barretos ( Site 1701) — Barretos
Alberta
- Cross Cancer Institute ( Site 0207) — Edmonton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2021-06-07 |
| Est. Completion | 2025-10-13 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04875195
The ClinicalTrials.gov registry entry for NCT04875195 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 66 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Hodgkin's Lymphoma appearing as the primary indexed condition, and to 1 intervention — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04875195 reports 20 study locations spanning 18 distinct geographic areas — top geographies include Other, Moscow, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04875195 about?
NCT04875195 is a clinical study titled "A Study of Pembrolizumab (MK-3475) in Relapsed or Refractory Classical Hodgkin's Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL) (MK-3475-B68)". The primary objective of the study is to evaluate the objective response rate (ORR), by cohort, rrcHL and rrPMBCL, as assessed by the investigator according to Lugano classification criteria 2014 in participants treated with pembrolizumab every six weeks (Q6W).
What is the current status of trial NCT04875195?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 66 participants. The study started on 2021-06-07. Estimated completion is 2025-10-13.
What conditions does trial NCT04875195 study?
This clinical trial studies the following conditions: Hodgkin's Lymphoma, Primary Mediastinal Large B-cell Lymphoma (PMBCL). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04875195?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04875195?
This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04875195 being conducted?
This trial has 20 study locations across California, Louisiana, Maryland, Paraná, São Paulo. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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