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NCT04786977 · ClinicalTrials.gov registry record

Physiologic Measure of VIPN

A clinical trial of Chemotherapy-induced Peripheral Neuropathy, sponsored by Children's National Research Institute.

Recruiting
Registry status
40
Enrollment target
1
Study location

NCT04786977: Recruiting study of Chemotherapy-induced Peripheral Neuropathy, sponsored by Children's National Research Institute.

NCT04786977 is a study of Chemotherapy-induced Peripheral Neuropathy that is actively recruiting participants, run by Children's National Research Institute. The registered enrollment target is 40 participants, below the 137-participant average among 29 other Chemotherapy-induced Peripheral Neuropathy trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04786977, a study of Chemotherapy-induced Peripheral Neuropathy, is actively recruiting participants, sponsored by Children's National Research Institute.

RECRUITING
Registry status
40 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is the development of a physiologic endpoint using a novel technology that would provide an objective, easy to use and more sensitive assessment of VIPN in children and adolescents. The ability to more easily detect and monitor VIPN, even before it is clinically evident, would facilitate optimizing the dosing of vincristine for maximal disease response while minimizing the risk of lifelong functional deficits affecting quality of life. This approach would also enable the development of specific therapies to minimize or eliminate the occurrence of VIPN in children and adolescents. This is a single site study that aims to develop a novel device to evaluate and characterize vincristine-induced neuropathic pain. The investigators will enroll patients with ALL following the Delayed Intensification (DI) phase of treatment. At each study visit, the investigators will evaluate the nPRD as well as the TNS-PV. The nPRD will inform the neuropathy index which will be used to compare to the TNS-PV. We anticipate a correlation between the two.

Primary Outcome

The primary objective of this study is the characterization of the neuropathy index in VIPN patients in order to measure VIPN severity.

Conditions Studied

Chemotherapy-induced Peripheral Neuropathy

Interventions

  • OTHER No Intervention, Observational Study

Study Locations (1)

District of Columbia

  • Children's National Health System - Washington D.C.

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 2021-09-20
Est. Completion 2025-12-01
Children's National Research Institute

92 total trials

What NCT04786977 shows while recruiting

NCT04786977 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 137-participant average among 29 other Chemotherapy-induced Peripheral Neuropathy trials with a reported enrollment target (71% lower).

The record links to 1 condition, with Chemotherapy-induced Peripheral Neuropathy appearing as the primary indexed condition, and to 1 intervention - of which No Intervention, Observational Study is the first listed.

NCT04786977 reports a single indexed study location in District of Columbia.

Frequently Asked Questions

What is clinical trial NCT04786977 about?

NCT04786977 is a clinical study titled "Physiologic Measure of VIPN". The purpose of this study is the development of a physiologic endpoint using a novel technology that would provide an objective, easy to use and more sensitive assessment of VIPN in children and adolescents. The ability to more easily detect and monitor VIPN, even before it is clinically evident, wo...

What is the current status of trial NCT04786977?

This trial is currently recruiting. The enrollment target is 40 participants. The study started on 2021-09-20. Estimated completion is 2025-12-01.

What conditions does trial NCT04786977 study?

This clinical trial studies the following conditions: Chemotherapy-induced Peripheral Neuropathy.

What interventions are being tested in trial NCT04786977?

The interventions under investigation include: No Intervention, Observational Study (OTHER).

Who is sponsoring clinical trial NCT04786977?

This trial is sponsored by Children's National Research Institute, which has 92 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04786977 being conducted?

This trial has 1 study location across District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Chemotherapy-induced Peripheral Neuropathy

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04786977's enrollment target sits among peer trials

40 18th of 29 higher than 12 of 29 other Chemotherapy-induced Peripheral Neuropathy trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Chemotherapy-induced Peripheral Neuropathy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT04786977

Source: ClinicalTrials.gov NCT04786977, the US trial registry maintained by the National Library of Medicine. NCT04786977 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.