Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04781673 · ClinicalTrials.gov registry record · Phase 4
Ketamine vs Lidocaine in Traumatic Rib Fractures
A Phase 4 study of Rib Fractures and Rib Fracture Multiple, sponsored by Brittany Hoyte.
- Active
- Registry status
- Phase 4
- Development phase
- 74
- Enrollment target
- 1
- Study location
NCT04781673: Active Phase 4 study of Rib Fractures and Rib Fracture Multiple, sponsored by Brittany Hoyte.
NCT04781673 is a Phase 4 study of Rib Fractures and Rib Fracture Multiple that is active but no longer recruiting, run by Brittany Hoyte. The registered enrollment target is 74 participants, below the 93-participant average among 9 other Rib Fractures trials with a reported enrollment target (20% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04781673, a Phase 4 study of Rib Fractures and Rib Fracture Multiple, is active but no longer recruiting, sponsored by Brittany Hoyte.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 74 participants
- Enrollment target
- 1
- Study location
Study Summary
Rib fractures continue to be a common occurrence in trauma patients of all ages. Traumatic rib fractures can cause severe pain in patients and lead to shallow breathing and further complications such as the need for mechanical ventilation, hospital or ventilator associated pneumonia, atelectasis, and acute respiratory distress syndrome. Effective multimodal pain management is needed to optimize a patient's respiratory status and can also play a role in early mobility, less pulmonary complications, shorter ICU and hospital length of stay, and decreased mortality. Current multimodal pain management options include opioids, muscle relaxants, gabapentin, acetaminophen, nonsteroidal anti-inflammatory drugs, and various regional/neuraxial anesthesia techniques. Both ketamine and lidocaine infusions for pain control have also been shown in studies to be safe and effective, with the benefit of minimizing the use of opioids. However, there have been very few studies that have used ketamine or lidocaine infusions for pain control specifically in patients with traumatic rib fractures. Therefore, the purpose of this study is to evaluate ketamine versus lidocaine infusions as an adjunctive therapy to reduce opioid consumption in the first 72 hours in patients with multiple traumatic rib fractures.
Primary Outcome
Oral morphine equivalence is a way to track the amount of opioids used by standardizing all opioid utilizations and converting them to daily morphine equivalence in mg.
Conditions Studied
Interventions
- DRUG Ketamine
- DRUG Lidocaine
Study Locations (1)
Michigan
- Corewell Health West - Grand Rapids
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2021-04-01 |
| Est. Completion | 2026-07 |
| Phase | Phase 4 |
What the registry record for NCT04781673 still lists
NCT04781673 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 74 participants, a relatively small participant target, below the 93-participant average among 9 other Rib Fractures trials with a reported enrollment target (20% lower).
The record links to 3 conditions, with Rib Fractures appearing as the primary indexed condition, and to 2 interventions - of which Ketamine is the first listed.
NCT04781673 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT04781673 about?
NCT04781673 is a clinical study titled "Ketamine vs Lidocaine in Traumatic Rib Fractures". Rib fractures continue to be a common occurrence in trauma patients of all ages. Traumatic rib fractures can cause severe pain in patients and lead to shallow breathing and further complications such as the need for mechanical ventilation, hospital or ventilator associated pneumonia, atelectasis, an...
What is the current status of trial NCT04781673?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 74 participants. The study started on 2021-04-01. Estimated completion is 2026-07.
What conditions does trial NCT04781673 study?
This clinical trial studies the following conditions: Rib Fractures, Rib Fracture Multiple, Rib Trauma.
What interventions are being tested in trial NCT04781673?
The interventions under investigation include: Ketamine (DRUG), Lidocaine (DRUG).
Who is sponsoring clinical trial NCT04781673?
This trial is sponsored by Brittany Hoyte, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04781673 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Rib Fractures
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04781673's enrollment target sits among peer trials
74 5th of 9 higher than 5 of 9 other Rib Fractures trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Rib Fractures trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures
RECRUITING · Phase 4
-
Cryo Rib Fracture Study
RECRUITING · Phase 4
-
Analgesic Techniques for Rib Fractures
ACTIVE NOT RECRUITING · Phase 4
-
Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients
COMPLETED · Phase 4
-
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
COMPLETED · Phase 4
-
Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03422731 · 74 participants · Early Phase 1
Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy
- NCT03804853 · 74 participants · NA
Rehabilitation Following Reverse Total Shoulder Arthroplasty
- NCT04065776 · 74 participants · NA
Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma
- NCT04771156 · 74 participants · Phase 4
Ketorolac in Palatoplasty
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI