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NCT04775004 · ClinicalTrials.gov registry record · NA
Comparing Meniscal Repair Biologic Augmentation: Marrow Venting Procedure Versus PRP (MVP Trial)
A NA study of Meniscal Tear, sponsored by University of Chicago.
- Active
- Registry status
- NA
- Development phase
- 146
- Enrollment target
- 3
- Study locations
NCT04775004 is a NA study of Meniscal Tear that is active but no longer recruiting, run by University of Chicago. The registered enrollment target is 146 participants. The trial reports 3 study locations across 3 states.
The verdict
NCT04775004, a NA study of Meniscal Tear, is active but no longer recruiting, sponsored by University of Chicago.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 146 participants
- Enrollment target
- 3
- Study locations
Study Summary
There are no current or past RCT comparing biologic augments for meniscal repair. There is good data supporting both the use of BMVP of the intercondylar notch and intra-articular PRP injections for augmentation of meniscal repair. However, the effectiveness of these augmentation methods with respect to each other has never been investigated. The knowledge gained will allow us to potentially influence and adapt protocols to treat this particular patient population. Additionally, resources available at our institution provide a supportive framework with which to maintain contact with patients after hospital discharge. These key factors will allow us to perform a robust analysis of this population, to include outcomes measures of function as well as meniscal repair failure and reoperation rate. The proposed interventional aim to compare meniscal repair augmentation methods is novel, as the direct comparison of these outcome measures has not been previously described. Because of the known benefit of biologic augmentation of meniscal repair, the investigators hypothesize that the repair failure rate for both cohorts will be lower than the reported repair failure rate for isolated tears without biologic augmentation; the investigators also hypothesize that BMVP of the intercondylar notch will clinically be significantly better than intra-articular PRP injection. The basis behind this hypothesis is in vivo evidence as well as a small RCT supporting the use of BMVP as augmentation for meniscal repair procedures.
Conditions Studied
Interventions
- OTHER Bone marrow venting procedure (BMVP)
- OTHER Platelet Rich Plasma (PRP)
Study Locations (3)
Florida
- University of Florida - Gainesville
Illinois
- University of Chicago Medicine - Chicago
North Carolina
- Wake Forest University Health Sciences - Winston-Salem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 146 participants |
| Start Date | 2021-07-19 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04775004
The ClinicalTrials.gov registry entry for NCT04775004 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 146 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Chicago, which has 796 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Meniscal Tear appearing as the primary indexed condition, and to 2 interventions - of which Bone marrow venting procedure (BMVP) is the first listed.
NCT04775004 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Florida, Illinois, North Carolina.
Frequently Asked Questions
What is clinical trial NCT04775004 about?
NCT04775004 is a clinical study titled "Comparing Meniscal Repair Biologic Augmentation: Marrow Venting Procedure Versus PRP (MVP Trial)". There are no current or past RCT comparing biologic augments for meniscal repair. There is good data supporting both the use of BMVP of the intercondylar notch and intra-articular PRP injections for augmentation of meniscal repair. However, the effectiveness of these augmentation methods with respec...
What is the current status of trial NCT04775004?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 146 participants. The study started on 2021-07-19. Estimated completion is 2026-12-31.
What conditions does trial NCT04775004 study?
This clinical trial studies the following conditions: Meniscal Tear.
What interventions are being tested in trial NCT04775004?
The interventions under investigation include: Bone marrow venting procedure (BMVP) (OTHER), Platelet Rich Plasma (PRP) (OTHER).
Who is sponsoring clinical trial NCT04775004?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04775004 being conducted?
This trial has 3 study locations across Florida, Illinois, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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