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NCT04750954 · ClinicalTrials.gov registry record · Phase 1
Testing the Addition of An Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Pancreatic Neuroendocrine Tumors
A Phase 1 study of Neuroendocrine Neoplasm, sponsored by National Cancer Institute (NCI).
- Active
- Registry status
- Phase 1
- Development phase
- 29
- Enrollment target
- 5
- Study locations
NCT04750954: Active Phase 1 study of Neuroendocrine Neoplasm, sponsored by National Cancer Institute (NCI).
NCT04750954 is a Phase 1 study of Neuroendocrine Neoplasm that is active but no longer recruiting, run by National Cancer Institute (NCI). The registered enrollment target is 29 participants, below the 127-participant average among 6 other Neuroendocrine Neoplasm trials with a reported enrollment target (77% lower). The trial reports 5 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04750954, a Phase 1 study of Neuroendocrine Neoplasm, is active but no longer recruiting, sponsored by National Cancer Institute (NCI).
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 29 participants
- Enrollment target
- 5
- Study locations
Study Summary
This phase Ib trial is to find out the best dose, possible benefits and/or side effects of peposertib when given together with lutetium Lu 177 dotatate in treating patients with neuroendocrine tumors. Peposertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell formation, so as to help block the formation of growths that may become cancer. Radioactive drugs, such as lutetium Lu 177 dotatate, may deliver radiation directly to tumor cells and not harm normal cells. Adding peposertib to lutetium Lu 177 dotatate may kill more tumor cells.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- PROCEDURE Computed Tomography
- PROCEDURE Magnetic Resonance Imaging
- DRUG Lutetium Lu 177 Dotatate
- DRUG Peposertib
Study Locations (5)
California
- City of Hope Comprehensive Cancer Center - Duarte
Florida
- University of Miami Miller School of Medicine-Sylvester Cancer Center - Miami
Kentucky
- University of Kentucky/Markey Cancer Center - Lexington
Ohio
- Ohio State University Comprehensive Cancer Center - Columbus
Utah
- Huntsman Cancer Institute/University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2021-07-22 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 1 |
What the registry record for NCT04750954 still lists
NCT04750954 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 127-participant average among 6 other Neuroendocrine Neoplasm trials with a reported enrollment target (77% lower).
The record links to 1 condition, with Neuroendocrine Neoplasm appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.
NCT04750954 lists 5 locations in 5 states (California, Florida, Kentucky).
Frequently Asked Questions
What is clinical trial NCT04750954 about?
NCT04750954 is a clinical study titled "Testing the Addition of An Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Pancreatic Neuroendocrine Tumors". This phase Ib trial is to find out the best dose, possible benefits and/or side effects of peposertib when given together with lutetium Lu 177 dotatate in treating patients with neuroendocrine tumors. Peposertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell forma...
What is the current status of trial NCT04750954?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 2021-07-22. Estimated completion is 2026-06-30.
What conditions does trial NCT04750954 study?
This clinical trial studies the following conditions: Neuroendocrine Neoplasm.
What interventions are being tested in trial NCT04750954?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Computed Tomography (PROCEDURE), Magnetic Resonance Imaging (PROCEDURE), Lutetium Lu 177 Dotatate (DRUG), Peposertib (DRUG).
Who is sponsoring clinical trial NCT04750954?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04750954 being conducted?
This trial has 5 study locations across California, Florida, Kentucky, Ohio, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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