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ACTIVE NOT RECRUITING Phase 2

Mogamulizumab Q4week Dosing in Participants With R/R CTCL

NCT04745234 · View on ClinicalTrials.gov ↗

Study Summary

This is an open-label, multicenter, Phase 2 study to evaluate the safety and tolerability of mogamulizumab given Q4W following initial weekly induction in adult participants with relapsed/refractory MF and SS subtypes of CTCL. The study is composed of a 28-day Screening Period during which participants are screened for entry into this study, followed by a treatment period of up to 2 years from Cycle 1 Day 1.

Interventions

  • DRUG Mogamulizumab

Study Locations (16)

Other

  • Hôpital Saint Louis — Paris
  • Azienda Ospedaliera Città della Salute e della Scienza di Torino — Turin
  • Hospital del Mar — Barcelona
  • Hospital Universitario 12 de Octubre — Madrid
  • Hospital Universitario Fundacion Jimenez Diaz — Madrid
  • Hospital Universitario De Salamanca — Salamanca
  • Queen Elizabeth Hospital — Birmingham
  • Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital — London
  • The Christie NHS Foundation Trust — Manchester

California

  • City of Hope National Medical Center — Duarte
  • University of California Irvine — Irvine
  • Stanford Cancer Center — Stanford

Louisiana

  • Tulane University School of Medicine — New Orleans

New York

  • New York Presbyterian Hospital — New York

Pennsylvania

  • University of Pittsburgh School of Medicine — Pittsburgh

Texas

  • MD Anderson Cancer Center — Houston

Trial Details

FieldValue
Enrollment Target 34 participants
Start Date 2021-08-16
Est. Completion 2025-05
Phase Phase 2

Sponsor

Kyowa Kirin

12 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04745234

The ClinicalTrials.gov registry entry for NCT04745234 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kyowa Kirin, which has 12 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Cutaneous T-Cell Lymphoma Refractory appearing as the primary indexed condition, and to 1 intervention — of which Mogamulizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04745234 reports 16 study locations spanning 6 distinct geographic areas — top geographies include Other, California, Louisiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04745234 about?

NCT04745234 is a clinical study titled "Mogamulizumab Q4week Dosing in Participants With R/R CTCL". This is an open-label, multicenter, Phase 2 study to evaluate the safety and tolerability of mogamulizumab given Q4W following initial weekly induction in adult participants with relapsed/refractory MF and SS subtypes of CTCL. The study is composed of a 28-day Screening Period during which participa...

What is the current status of trial NCT04745234?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 34 participants. The study started on 2021-08-16. Estimated completion is 2025-05.

What conditions does trial NCT04745234 study?

This clinical trial studies the following conditions: Cutaneous T-Cell Lymphoma Refractory, Cutaneous T-Cell Lymphoma, Relapsed. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04745234?

The interventions under investigation include: Mogamulizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04745234?

This trial is sponsored by Kyowa Kirin, which has 12 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04745234 being conducted?

This trial has 16 study locations across California, Louisiana, New York, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial