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NCT04740684 · ClinicalTrials.gov registry record · NA
Microbiome Individuality and Stability Over Time
A NA study of Diet, sponsored by Stanford University.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
- 1
- Study location
NCT04740684: Completed NA study of Diet, sponsored by Stanford University.
NCT04740684 is a NA study of Diet that has completed, run by Stanford University. The registered enrollment target is 21 participants, below the 435-participant average among 17 other Diet trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04740684, a NA study of Diet, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
- 1
- Study location
Study Summary
Microbial derived uremic solutes (p-cresol sulfate, indoxyl sulfate, and phenylacetylglutamine) are present in blood and excreted into the urine. Uremic solutes have high inter-individual variability of unclear etiology, that the investigators hypothesize is due to intestinal microbiome variation and/or dietary variation between people. In this study, the investigators will collect baseline samples on participant's habitual diet. The investigators will then administer a homogenous diet to all participants for 7 days and examine levels of uremic solutes in the urine via 24-hour urine collection during this period. In parallel, the investigators will monitor microbiome composition. The investigators predict that during the period subjects are consuming the same, homogenous diet, their excretion of uremic solutes (p-cresol sulfate, indoxyl sulfate, and phenylacetylglutamine) into the urine will have less inter-individual variation.
Primary Outcome
25% reduction of the coefficient of variation of 24hr urinary excretion of at least 1 of 3 uremic solutes (p-cresol sulfate, indoxyl sulfate or phenylacetylglutamine) measured in mg/day/1.73 during the homogenous diet period as compared to the baseline/habitual diet period.
Conditions Studied
Interventions
- OTHER Standardized diet
Study Locations (1)
California
- Stanford University - Stanford
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2018-08-06 |
| Est. Completion | 2019-02-11 |
| Phase | NA |
What the finished NCT04740684 record still lists
NCT04740684 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 435-participant average among 17 other Diet trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Diet appearing as the primary indexed condition, and to 1 intervention - of which Standardized diet is the first listed.
NCT04740684 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04740684 about?
NCT04740684 is a clinical study titled "Microbiome Individuality and Stability Over Time". Microbial derived uremic solutes (p-cresol sulfate, indoxyl sulfate, and phenylacetylglutamine) are present in blood and excreted into the urine. Uremic solutes have high inter-individual variability of unclear etiology, that the investigators hypothesize is due to intestinal microbiome variation an...
What is the current status of trial NCT04740684?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2018-08-06. Estimated completion is 2019-02-11.
What conditions does trial NCT04740684 study?
This clinical trial studies the following conditions: Diet.
What interventions are being tested in trial NCT04740684?
The interventions under investigation include: Standardized diet (OTHER).
Who is sponsoring clinical trial NCT04740684?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04740684 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04740684's enrollment target sits among peer trials
21 16th of 17 higher than 2 of 17 other Diet trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diet trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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