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Study to Assess the Efficacy of Anti-Bet v 1 Monoclonal Antibodies in Adults to Reduce Symptoms of Seasonal Allergic Rhinitis
NCT04709575 · View on ClinicalTrials.gov ↗
Study Summary
The primary objective is to assess the reduction of allergic symptoms as measured by combined symptom and medication score (CSMS) during birch pollen season after a single dose of REGN5713-5714-5715 versus placebo.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG REGN5713
- DRUG REGN5715
- DRUG REGN5714
Study Locations (20)
Ontario
- Regeneron Study Site — Kingston
- Regeneron Study Site — London
- Regeneron Study Site — Ottawa
- Regeneron Study Site — Toronto
Missouri
- Regeneron Study Site — Columbia
- Regeneron Study Site — St Louis
Ohio
- Regeneron Study Site — Cincinnati
- Regeneron Study Site — Toledo
Maine
- Regeneron Study Site — Bangor
Maryland
- Regeneron Study Site — Baltimore
Minnesota
- Regeneron Study Site — Plymouth
Montana
- Regeneron Study Site — Missoula
New Jersey
- Regeneron Study Site — Verona
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 353 participants |
| Start Date | 2021-01-14 |
| Est. Completion | 2021-08-24 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04709575
The ClinicalTrials.gov registry entry for NCT04709575 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 353 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Regeneron Pharmaceuticals, which has 290 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Allergic Rhinitis appearing as the primary indexed condition, and to 4 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04709575 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Ontario, Missouri, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04709575 about?
NCT04709575 is a clinical study titled "Study to Assess the Efficacy of Anti-Bet v 1 Monoclonal Antibodies in Adults to Reduce Symptoms of Seasonal Allergic Rhinitis". The primary objective is to assess the reduction of allergic symptoms as measured by combined symptom and medication score (CSMS) during birch pollen season after a single dose of REGN5713-5714-5715 versus placebo.
What is the current status of trial NCT04709575?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 353 participants. The study started on 2021-01-14. Estimated completion is 2021-08-24.
What conditions does trial NCT04709575 study?
This clinical trial studies the following conditions: Allergic Rhinitis, Conjunctivitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04709575?
The interventions under investigation include: Placebo (DRUG), REGN5713 (DRUG), REGN5715 (DRUG), REGN5714 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04709575?
This trial is sponsored by Regeneron Pharmaceuticals, which has 290 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04709575 being conducted?
This trial has 20 study locations across Maine, Maryland, Minnesota, Missouri, Montana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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