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NCT04670965 · ClinicalTrials.gov registry record
Release Kinetics of rhBMP-2 Using E-PRF as an Autologous Carrier: An In Vitro Analysis
A clinical trial, sponsored by University of Alabama at Birmingham.
- Not yet
- Registry status
- 20
- Enrollment target
NCT04670965: Clinical Trial study, sponsored by University of Alabama at Birmingham.
NCT04670965 is a clinical trial that has not yet begun recruiting, run by University of Alabama at Birmingham. The registered enrollment target is 20 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04670965 has not yet begun recruiting, sponsored by University of Alabama at Birmingham.
- NOT YET RECRUITING
- Registry status
- 20 participants
- Enrollment target
Study Summary
This study is seeking to evaluate the binding of a commercially-available, recombinant human osteoinductive growth factor, rhBMP-2, to a human blood derived product scaffold, enhanced Platelet-rich fibrin (E-PRF), and the release of such a growth factor over time in an in vitro (laboratory) environment. The investigators will compare these release kinetics to those of the FDA approved carrier for rhBMP-2, an absorbable collagen sponge (ACS), a combination of E-PRF and ACS, and E-PRF alone.
Primary Outcome
The quanitites of rhBMP-2 at all time points from all groups will be compared using statistical analysis by two-way ANOVA with Bonferroni test.
Interventions
- BIOLOGICAL E-PRF/rhBMP-2 (similar ratios)
- BIOLOGICAL E-PRF/ACS/rhBMP-2
- BIOLOGICAL rhBMP-2/E-PRF
- BIOLOGICAL E-PRF only
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-09 |
| Est. Completion | 2028-07 |
What is known before NCT04670965 opens enrollment
NCT04670965 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 20 participants, a relatively small participant target.
The record links to 0 conditions, and to 4 interventions - of which E-PRF/rhBMP-2 (similar ratios) is the first listed.
NCT04670965 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04670965 about?
NCT04670965 is a clinical study titled "Release Kinetics of rhBMP-2 Using E-PRF as an Autologous Carrier: An In Vitro Analysis". This study is seeking to evaluate the binding of a commercially-available, recombinant human osteoinductive growth factor, rhBMP-2, to a human blood derived product scaffold, enhanced Platelet-rich fibrin (E-PRF), and the release of such a growth factor over time in an in vitro (laboratory) environm...
What is the current status of trial NCT04670965?
This trial is currently not yet recruiting. The enrollment target is 20 participants. The study started on 2026-09. Estimated completion is 2028-07.
What interventions are being tested in trial NCT04670965?
The interventions under investigation include: E-PRF/rhBMP-2 (similar ratios) (BIOLOGICAL), E-PRF/ACS/rhBMP-2 (BIOLOGICAL), rhBMP-2/E-PRF (BIOLOGICAL), E-PRF only (BIOLOGICAL).
Who is sponsoring clinical trial NCT04670965?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
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