Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy
NCT04629248 · View on ClinicalTrials.gov ↗
Study Summary
This study will evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics (PK) of obinutuzumab compared with tacrolimus in participants with primary membranous nephropathy (pMN).
Conditions Studied
Interventions
- DRUG Obinutuzumab
- DRUG Acetaminophen
- DRUG Methylprednisolone
- DRUG Diphenhydramine
- DRUG Tacrolimus
Study Locations (20)
Other
- Organizacion Medica de Investigacion — Buenos Aires
- CINME — Buenos Aires
- Hospital Britanico Buenos Aires — Buenos Aires
- Peking University First Hospital — Beijing
- Sichuan Provincial People's Hospital — Chengdu
- The 1st Affiliated hospital of Fujian Medical University — Fuzhou
- Nanfang Hospital, Southern Medical University — Guangzhou
São Paulo
- Hospital de Base de Sao Jose do Rio Preto — São José do Rio Preto
- Hospital do Rim e Hipertensão - Fundação Oswaldo Ramos — São Paulo
- Hospital das Clinicas - FMUSP — São Paulo
California
- Kaiser Permanente - San Francisco Medical Center — San Francisco
Colorado
- University of Colorado in Denver-Anschutz Medical Campus — Aurora
Florida
- Accel Research Sites; Mid-Florida Kidney and Hypertension Care — Altamonte Springs
Iowa
- University of Iowa — Iowa City
Michigan
- Henry Ford Hospital — Detroit
Minnesota
- Mayo Clinic — Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 142 participants |
| Start Date | 2021-06-25 |
| Est. Completion | 2027-12-21 |
| Phase | Phase 3 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04629248
The ClinicalTrials.gov registry entry for NCT04629248 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 142 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Primary Membranous Nephropathy appearing as the primary indexed condition, and to 5 interventions — of which Obinutuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04629248 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, São Paulo, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04629248 about?
NCT04629248 is a clinical study titled "A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy". This study will evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics (PK) of obinutuzumab compared with tacrolimus in participants with primary membranous nephropathy (pMN).
What is the current status of trial NCT04629248?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 142 participants. The study started on 2021-06-25. Estimated completion is 2027-12-21.
What conditions does trial NCT04629248 study?
This clinical trial studies the following conditions: Primary Membranous Nephropathy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04629248?
The interventions under investigation include: Obinutuzumab (DRUG), Acetaminophen (DRUG), Methylprednisolone (DRUG), Diphenhydramine (DRUG), Tacrolimus (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04629248?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04629248 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Iowa, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.