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COMPLETED Phase 2

A Study of Adavosertib as Treatment for Uterine Serous Carcinoma

NCT04590248 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 2b study aims to evaluate the efficacy and safety of adavosertib, an inhibitor of the tyrosine kinase WEE1, in subjects with recurrent or persistent uterine serous carcinoma (USC) who have previously received at least 1 prior platinum-based chemotherapy regimen for the management of USC.

Conditions Studied

Interventions

  • DRUG Adavosertib

Study Locations (20)

Other

  • Research Site — Toronto
  • Research Site — Dijon
  • Research Site — Marseille
  • Research Site — Nice
  • Research Site — Pierre-Bénite
  • Research Site — Saint-Herblain

California

  • Research Site — Burbank
  • Research Site — Duarte
  • Research Site — La Jolla
  • Research Site — West Hollywood

New York

  • Research Site — New York
  • Research Site — The Bronx

Washington

  • Research Site — Spokane
  • Research Site — Vancouver

Colorado

  • Research Site — Aurora

Iowa

  • Research Site — Iowa City

Louisiana

  • Research Site — Covington

Massachusetts

  • Research Site — Boston

Trial Details

FieldValue
Enrollment Target 109 participants
Start Date 2020-11-30
Est. Completion 2023-02-07
Phase Phase 2

Sponsor

AstraZeneca

1,053 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04590248

The ClinicalTrials.gov registry entry for NCT04590248 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 109 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Uterine Serous Carcinoma appearing as the primary indexed condition, and to 1 intervention — of which Adavosertib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04590248 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Other, California, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04590248 about?

NCT04590248 is a clinical study titled "A Study of Adavosertib as Treatment for Uterine Serous Carcinoma". This Phase 2b study aims to evaluate the efficacy and safety of adavosertib, an inhibitor of the tyrosine kinase WEE1, in subjects with recurrent or persistent uterine serous carcinoma (USC) who have previously received at least 1 prior platinum-based chemotherapy regimen for the management of USC.

What is the current status of trial NCT04590248?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 109 participants. The study started on 2020-11-30. Estimated completion is 2023-02-07.

What conditions does trial NCT04590248 study?

This clinical trial studies the following conditions: Uterine Serous Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04590248?

The interventions under investigation include: Adavosertib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04590248?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04590248 being conducted?

This trial has 20 study locations across California, Colorado, Iowa, Louisiana, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial