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A Prospective Natural History Study in Uveal Melanoma
NCT04588662 · View on ClinicalTrials.gov ↗
Study Summary
The overall objective of this proposal is to develop and utilize a multicenter UM registry that will, in a longitudinal fashion, capture prospective data in order to characterize the natural history of UM and provide data that will be used to support the development of novel therapies for this disease. The care of patients with UM requires a multi-disciplinary team of physicians that commonly requires the involvement of both radiation oncology and interventional radiology, and is typically directed by an ophthalmologic oncologist at time of initial diagnosis of primary disease. Overall management is transitioned to a medical oncologist when distant recurrence is identified. In the case that a patient presents with metastasis at the time of diagnosis, a medical oncologist typically directs overall management. The management of surveillance for the development of metastasis following the treatment of primary disease is variable and, if performed at all, is managed by either an ophthalmologic oncologist or medical oncologist. Thus, the successful development of a registry that aims to capture the data regarding the full natural history of UM requires a collaborative effort including leaders from both the UM ophthalmologic oncology and medical oncology fields. To this end, the investigators have built an initial consortium of key ophthalmologic oncology and medical oncology leaders from multiple major UM centers in the United States.
Conditions Studied
Study Locations (17)
Other
- Royal Adelaide Hospital — Adelaide
- Chatswood Eye Specialists — Chatswood
- Royal Victorian Eve and Ear Hospital — East Melbourne
- Western Eye Specialists — Maribyrnong
- Pennington Eye Clinic — North Adelaide
- Perth Retina — Subiaco
- Dr. Conway Private Rooms — Sydney
- St. Vincent's Hospital — Sydney
- Princess Margaret Cancer Center — Toronto
- Erlangen — Erlangen
- Clatterbridge Cancer Centre — Birkenhead
- Mount Vernon Cancer Centre — Northwood
- Sheffield — Sheffield
Massachusetts
- Massachusetts General Hospital — Boston
New York
- Memorial Sloan Kettering Cancer Center — New York
Pennsylvania
- Thomas Jefferson University Hospital — Philadelphia
Texas
- MD Anderson Cancer Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 122 participants |
| Start Date | 2021-05-06 |
| Est. Completion | 2026-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04588662
The ClinicalTrials.gov registry entry for NCT04588662 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 122 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Columbia University, which has 875 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Uveal Melanoma appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04588662 reports 17 study locations spanning 5 distinct geographic areas — top geographies include Other, Massachusetts, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04588662 about?
NCT04588662 is a clinical study titled "A Prospective Natural History Study in Uveal Melanoma". The overall objective of this proposal is to develop and utilize a multicenter UM registry that will, in a longitudinal fashion, capture prospective data in order to characterize the natural history of UM and provide data that will be used to support the development of novel therapies for this disea...
What is the current status of trial NCT04588662?
This trial is currently active not recruiting. The enrollment target is 122 participants. The study started on 2021-05-06. Estimated completion is 2026-07.
What conditions does trial NCT04588662 study?
This clinical trial studies the following conditions: Uveal Melanoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT04588662?
This trial is sponsored by Columbia University, which has 875 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04588662 being conducted?
This trial has 17 study locations across Massachusetts, New York, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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