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ACTIVE NOT RECRUITING Phase 1

Study of Zifibancimig in Participants With Neovascular Age-related Macular Degeneration

NCT04567303 · View on ClinicalTrials.gov ↗

Study Summary

This is a first in-human study to investigate the safety, tolerability and efficacy of zifibancimig administered through intravitreal (IVT) injections and via the port delivery (PD) implant in participants with neovascular age-related macular degeneration (nAMD).

Conditions Studied

Interventions

  • DRUG Zifibancimig
  • DRUG Ranibizumab
  • DEVICE Port Delivery Platform

Study Locations (20)

California

  • The Retina Partners — Encino
  • Retinal Consultants Med Group — Sacramento
  • Orange County Retina Med Group — Santa Ana
  • Macula Retina Vitreous Research Institute — Torrance

Florida

  • Retina Specialty Institute — Pensacola
  • Retina Vitreous Assoc of FL — St. Petersburg
  • Southern Vitreoretinal Assoc — Tallahassee
  • Retina Associates of Florida, LLC — Tampa

Maryland

  • The Retina Care Center — Baltimore
  • Johns Hopkins Med — Baltimore
  • Retina Group of Washington — Chevy Chase
  • Cumberland Valley Retina Consultants — Hagerstown

Arizona

  • Barnet Dulaney Perkins Eye Center — Mesa
  • Associated Retina Consultants — Phoenix

Michigan

  • Foundation for Vision Research — Grand Rapids
  • Associated Retinal Consultants — Royal Oak

Colorado

  • Southwest Retina Consultants — Durango

Georgia

  • Southeast Retina Center — Augusta

Illinois

  • University Retina and Macula Associates, PC — Oak Forest

Trial Details

FieldValue
Enrollment Target 177 participants
Start Date 2020-10-28
Est. Completion 2026-08-01
Phase Phase 1

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04567303

The ClinicalTrials.gov registry entry for NCT04567303 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 177 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Macular Degeneration appearing as the primary indexed condition, and to 3 interventions — of which Zifibancimig is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04567303 reports 20 study locations spanning 9 distinct geographic areas — top geographies include California, Florida, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04567303 about?

NCT04567303 is a clinical study titled "Study of Zifibancimig in Participants With Neovascular Age-related Macular Degeneration". This is a first in-human study to investigate the safety, tolerability and efficacy of zifibancimig administered through intravitreal (IVT) injections and via the port delivery (PD) implant in participants with neovascular age-related macular degeneration (nAMD).

What is the current status of trial NCT04567303?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 177 participants. The study started on 2020-10-28. Estimated completion is 2026-08-01.

What conditions does trial NCT04567303 study?

This clinical trial studies the following conditions: Macular Degeneration. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04567303?

The interventions under investigation include: Zifibancimig (DRUG), Ranibizumab (DRUG), Port Delivery Platform (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04567303?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04567303 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial