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RECRUITING

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

NCT04561518 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to: * Describe epidemiological and clinical characteristics, natural history and real-world clinical management of ATTR amyloidosis patients * Characterize the safety and effectiveness of patisiran and vutrisiran as part of routine clinical practice in the real-world clinical setting * Describe disease emergence/progression in pre-symptomatic carriers of a known disease-causing transthyretin (TTR) variant

Study Locations (20)

Other

  • Clinical Trial Site — Salvador
  • Clinical Trial Site — São Paulo
  • Clinical Trial Site — Sofia
  • Clinical Trial Site — Aarhus
  • Clinical Trial Site — Copenhagen
  • Clinical Trial Site — Bordeaux
  • Clinical Trial Site — Bron

California

  • Clinical Trial Site — La Jolla
  • Clinical Trial Site — Los Angeles

Texas

  • Clinical Trial Site — Austin
  • Clinical Trial Site — Houston

Florida

  • Clinical Trial Site — Jacksonville

Iowa

  • Clinical Trial Site — Iowa City

Kansas

  • Clinical Trial Site — Kansas City

Maryland

  • Clinical Trial Site — Baltimore

Massachusetts

  • Clinical Trial Site — Boston

Trial Details

FieldValue
Enrollment Target 1,500 participants
Start Date 2020-11-23
Est. Completion 2030-09-01

Sponsor

Alnylam Pharmaceuticals

81 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04561518

The ClinicalTrials.gov registry entry for NCT04561518 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,500 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alnylam Pharmaceuticals, which has 81 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with ATTR Amyloidosis appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04561518 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, California, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04561518 about?

NCT04561518 is a clinical study titled "ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)". The purpose of this study is to: * Describe epidemiological and clinical characteristics, natural history and real-world clinical management of ATTR amyloidosis patients * Characterize the safety and effectiveness of patisiran and vutrisiran as part of routine clinical practice in the real-world cl...

What is the current status of trial NCT04561518?

This trial is currently recruiting. The enrollment target is 1,500 participants. The study started on 2020-11-23. Estimated completion is 2030-09-01.

What conditions does trial NCT04561518 study?

This clinical trial studies the following conditions: ATTR Amyloidosis, Transthyretin-Mediated Amyloidosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

Who is sponsoring clinical trial NCT04561518?

This trial is sponsored by Alnylam Pharmaceuticals, which has 81 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04561518 being conducted?

This trial has 20 study locations across California, Florida, Iowa, Kansas, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial