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NCT04231708 · ClinicalTrials.gov registry record · Phase 2
Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
A Phase 2 study, sponsored by Wayne State University.
- Not yet
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
NCT04231708: Clinical Trial Phase 2 study, sponsored by Wayne State University.
NCT04231708 is a Phase 2 study that has not yet begun recruiting, run by Wayne State University. The registered enrollment target is 20 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04231708, a Phase 2 study, has not yet begun recruiting, sponsored by Wayne State University.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
Study Summary
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs. placebo) alter behavior in non-treatment seeking individuals with opioid use disorder (OUD). Specific Aims are to (1) Evaluate how stress impacts domains of behavior including (1a) executive function and (1b) opioid-seeking behavior; and (2) Determine whether rTMS stimulation attenuates (2a) executive dysfunction, (2b) stress-reactivity, and (2c) opioid-seeking in individuals with OUD not receiving treatment.
Primary Outcome
measures cognitive control in response to opioid-related words.
Interventions
- DRUG Placebo
- DEVICE Active rTMS
- DEVICE Sham rTMS
- DRUG Yohimbine + Hydrocortisone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-10 |
| Est. Completion | 2028-12 |
| Phase | Phase 2 |
What is known before NCT04231708 opens enrollment
NCT04231708 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT04231708 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04231708 about?
NCT04231708 is a clinical study titled "Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder". This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs. placebo) alter behavior in non-treatment seeking individuals with opioid use disorder (O...
What is the current status of trial NCT04231708?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2026-10. Estimated completion is 2028-12.
What interventions are being tested in trial NCT04231708?
The interventions under investigation include: Placebo (DRUG), Active rTMS (DEVICE), Sham rTMS (DEVICE), Yohimbine + Hydrocortisone (DRUG).
Who is sponsoring clinical trial NCT04231708?
This trial is sponsored by Wayne State University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04231708's enrollment target sits among peer trials
20 1805th of 2000 higher than 107 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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