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NCT04231708 · ClinicalTrials.gov registry record · Phase 2
Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
A Phase 2 study, sponsored by Wayne State University.
- Not yet
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
NCT04231708 is a Phase 2 study that has not yet begun recruiting, run by Wayne State University. The registered enrollment target is 20 participants.
The verdict
NCT04231708, a Phase 2 study, has not yet begun recruiting, sponsored by Wayne State University.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
Study Summary
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs. placebo) alter behavior in non-treatment seeking individuals with opioid use disorder (OUD). Specific Aims are to (1) Evaluate how stress impacts domains of behavior including (1a) executive function and (1b) opioid-seeking behavior; and (2) Determine whether rTMS stimulation attenuates (2a) executive dysfunction, (2b) stress-reactivity, and (2c) opioid-seeking in individuals with OUD not receiving treatment.
Interventions
- DRUG Placebo
- DEVICE Active rTMS
- DEVICE Sham rTMS
- DRUG Yohimbine + Hydrocortisone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-10 |
| Est. Completion | 2028-12 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04231708
The ClinicalTrials.gov registry entry for NCT04231708 describes a study currently listed as not yet recruiting, categorized as Phase 2. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Wayne State University, which has 163 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT04231708 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04231708 about?
NCT04231708 is a clinical study titled "Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder". This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs. placebo) alter behavior in non-treatment seeking individuals with opioid use disorder (O...
What is the current status of trial NCT04231708?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2026-10. Estimated completion is 2028-12.
What interventions are being tested in trial NCT04231708?
The interventions under investigation include: Placebo (DRUG), Active rTMS (DEVICE), Sham rTMS (DEVICE), Yohimbine + Hydrocortisone (DRUG).
Who is sponsoring clinical trial NCT04231708?
This trial is sponsored by Wayne State University, which has 163 total clinical trials registered on ClinicalTrials.gov.
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