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NCT04155632 · ClinicalTrials.gov registry record · Phase 2
Neurocircuit Strategy to Decrease Cocaine Cue Reactivity
A Phase 2 study, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- Phase 2
- Development phase
- 32
- Enrollment target
NCT04155632: Completed Phase 2 study, sponsored by Medical University of South Carolina.
NCT04155632 is a Phase 2 study that has completed, run by Medical University of South Carolina. The registered enrollment target is 32 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (76% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04155632, a Phase 2 study, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 32 participants
- Enrollment target
Study Summary
The overarching goal of this project is to examine the effect of combining theta burst stimulation (TBS) and N-acetylcysteine (NAC) on cocaine craving and brain response to cocaine-related images.
Primary Outcome
Measured using fMRI during cocaine cue reactivity task. Percent BOLD signal change in OFC from baseline (Visit 2) to post-TBS (Visit 3). Measured using functional MRI during a cocaine cue reactivity task. The outcome reflects the change in raw BOLD signal in the orbitofrontal cortex (OFC) between baseline and post-TBS sessions. Signal change was calculated by comparing activation during cocaine-related image blocks versus neutral image blocks. Values are reported as raw BOLD signal units (not pe
Interventions
- DRUG N-acetylcysteine
- DEVICE Theta-burst stimulation (TBS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2020-12-18 |
| Est. Completion | 2023-03-09 |
| Phase | Phase 2 |
What the finished NCT04155632 record still lists
NCT04155632 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (76% lower).
The record links to 0 conditions, and to 2 interventions - of which N-acetylcysteine is the first listed.
NCT04155632 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04155632 about?
NCT04155632 is a clinical study titled "Neurocircuit Strategy to Decrease Cocaine Cue Reactivity". The overarching goal of this project is to examine the effect of combining theta burst stimulation (TBS) and N-acetylcysteine (NAC) on cocaine craving and brain response to cocaine-related images.
What is the current status of trial NCT04155632?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 32 participants. The study started on 2020-12-18. Estimated completion is 2023-03-09.
What interventions are being tested in trial NCT04155632?
The interventions under investigation include: N-acetylcysteine (DRUG), Theta-burst stimulation (TBS) (DEVICE).
Who is sponsoring clinical trial NCT04155632?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04155632's enrollment target sits among peer trials
32 1563rd of 2000 higher than 423 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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