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ACTIVE NOT RECRUITING Phase 1

A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies

NCT04104672 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 1, open-label, dose-escalation, and dose-expansion, with a gated randomization portion, study to evaluate the safety, tolerability, pharmacokinetic, pharmacodynamic and clinical activity of AB680 in combination with zimberelimab (AB122), nab-paclitaxel and gemcitabine in participants with advanced pancreatic cancer.

Conditions Studied

Interventions

  • DRUG Gemcitabine
  • DRUG Zimberelimab
  • DRUG Nab-paclitaxel
  • DRUG AB680

Study Locations (14)

New York

  • NYU Cancer Institute — New York
  • Columbia University — New York
  • Memorial Sloan Kettering Cancer Center — New York

California

  • The Angeles Clinic — Los Angeles
  • UCLA Hematology Oncology — Santa Monica

Pennsylvania

  • University of Pennsylvania — Philadelphia
  • UPMC Hillman Cancer Center — Pittsburgh

Texas

  • The University of Texas MD Anderson Cancer Center — Houston
  • START San Antonio — San Antonio

Missouri

  • Washington University School of Medicine - Siteman Cancer Center — St Louis

Oklahoma

  • Stephenson Cancer Center — Oklahoma City

Tennessee

  • Sarah Canon Research Institute — Nashville

Washington

  • Medical Oncology Associates — Spokane

Trial Details

FieldValue
Enrollment Target 196 participants
Start Date 2019-11-06
Est. Completion 2027-05
Phase Phase 1

Sponsor

Arcus Biosciences

14 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04104672

The ClinicalTrials.gov registry entry for NCT04104672 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 196 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arcus Biosciences, which has 14 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced Pancreatic Cancer appearing as the primary indexed condition, and to 4 interventions — of which Gemcitabine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04104672 reports 14 study locations spanning 9 distinct geographic areas — top geographies include New York, California, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04104672 about?

NCT04104672 is a clinical study titled "A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies". This is a Phase 1, open-label, dose-escalation, and dose-expansion, with a gated randomization portion, study to evaluate the safety, tolerability, pharmacokinetic, pharmacodynamic and clinical activity of AB680 in combination with zimberelimab (AB122), nab-paclitaxel and gemcitabine in participants...

What is the current status of trial NCT04104672?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 196 participants. The study started on 2019-11-06. Estimated completion is 2027-05.

What conditions does trial NCT04104672 study?

This clinical trial studies the following conditions: Advanced Pancreatic Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04104672?

The interventions under investigation include: Gemcitabine (DRUG), Zimberelimab (DRUG), Nab-paclitaxel (DRUG), AB680 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04104672?

This trial is sponsored by Arcus Biosciences, which has 14 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04104672 being conducted?

This trial has 14 study locations across California, Missouri, New York, Oklahoma, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial