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ACTIVE NOT RECRUITING Phase 1

Safety and Efficacy of ALLO-715 BCMA Allogenic CAR T Cells in in Adults With Relapsed or Refractory Multiple Myeloma (UNIVERSAL)

NCT04093596 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of the UNIVERSAL study is to assess the safety, efficacy, cell kinetics, and immunogenicity of ALLO-715 with or without Nirogacestat in adults with relapsed or refractory multiple myeloma after a lymphodepletion regimen of ALLO-647 in combination with fludarabine and/or cyclophosphamide, or ALLO-647 alone.

Interventions

  • DRUG Cyclophosphamide
  • DRUG Fludarabine
  • DRUG Nirogacestat
  • BIOLOGICAL ALLO-647
  • GENETIC ALLO-715

Study Locations (11)

California

  • City of Hope — Duarte
  • Stanford Cancer Institute — Palo Alto

Texas

  • St. David's South Austin Medical Center — Austin
  • Texas Transplant Institute — San Antonio

Arizona

  • Banner MD Anderson Cancer Center — Gilbert

Colorado

  • Sarah Cannon/Colorado Blood Cancer Institute — Denver

Minnesota

  • Mayo Clinic — Rochester

New York

  • Memorial Sloan Kettering Cancer Center — New York

Ohio

  • Cleveland Clinic Taussig Cancer Center — Cleveland

Tennessee

  • Vanderbilt-Ingram Cancer Center — Nashville

Trial Details

FieldValue
Enrollment Target 132 participants
Start Date 2019-09-23
Est. Completion 2027-09
Phase Phase 1

Sponsor

Allogene Therapeutics

5 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04093596

The ClinicalTrials.gov registry entry for NCT04093596 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 132 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Allogene Therapeutics, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Relapsed/Refractory Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04093596 reports 11 study locations spanning 9 distinct geographic areas — top geographies include California, Texas, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04093596 about?

NCT04093596 is a clinical study titled "Safety and Efficacy of ALLO-715 BCMA Allogenic CAR T Cells in in Adults With Relapsed or Refractory Multiple Myeloma (UNIVERSAL)". The purpose of the UNIVERSAL study is to assess the safety, efficacy, cell kinetics, and immunogenicity of ALLO-715 with or without Nirogacestat in adults with relapsed or refractory multiple myeloma after a lymphodepletion regimen of ALLO-647 in combination with fludarabine and/or cyclophosphamide,...

What is the current status of trial NCT04093596?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 132 participants. The study started on 2019-09-23. Estimated completion is 2027-09.

What conditions does trial NCT04093596 study?

This clinical trial studies the following conditions: Relapsed/Refractory Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04093596?

The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Nirogacestat (DRUG), ALLO-647 (BIOLOGICAL), ALLO-715 (GENETIC). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04093596?

This trial is sponsored by Allogene Therapeutics, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04093596 being conducted?

This trial has 11 study locations across Arizona, California, Colorado, Minnesota, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial