Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

CASCARA: Castration Sensitive Carboplatin, Cabazitaxel and Abiraterone

NCT03934840 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase II clinical trial in patients with metastatic castration sensitive prostate cancer. The objective of the study is to determine the efficacy and further define the safety of the treatment combination. This study will evaluate dose levels of carboplatin AUC 4 with cabazitaxel 20 mg/m2. Patients will be treated with the combination of ADT and carboplatin and cabazitaxel for 6 cycles. After 6 cycles of chemotherapy, they will start abiraterone with ADT. The primary objective is to determine the percent of subjects that have no PSA or radiographic progression at 1 year. Secondary objectives will include determining the progression-free survival, time to PSA nadir and time to PSA progression of carboplatin and cabazitaxel in combination with ADT.

Conditions Studied

Interventions

  • DRUG Carboplatin
  • DRUG Prednisone
  • DRUG Abiraterone
  • DRUG Cabazitaxel

Study Locations (8)

Illinois

  • Northwestern University — Chicago
  • University of Chicago — Chicago

Arizona

  • Mayo Clinic Arizona — Phoenix

Louisiana

  • Tulane University — New Orleans

Minnesota

  • Masonic Cancer Center at University of Minnesota — Minneapolis

Nevada

  • Comprehensive Cancer Centers of Nevada — Las Vegas

Pennsylvania

  • Thomas Jeferson University — Philadelphia

Rhode Island

  • Lifespan Cancer Institute — Providence

Trial Details

FieldValue
Enrollment Target 22 participants
Start Date 2019-10-10
Est. Completion 2025-05
Phase Phase 2

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03934840

The ClinicalTrials.gov registry entry for NCT03934840 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 22 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Masonic Cancer Center, University of Minnesota, which has 154 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Prostate Cancer appearing as the primary indexed condition, and to 4 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03934840 reports 8 study locations spanning 7 distinct geographic areas — top geographies include Illinois, Arizona, Louisiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03934840 about?

NCT03934840 is a clinical study titled "CASCARA: Castration Sensitive Carboplatin, Cabazitaxel and Abiraterone". This is a phase II clinical trial in patients with metastatic castration sensitive prostate cancer. The objective of the study is to determine the efficacy and further define the safety of the treatment combination. This study will evaluate dose levels of carboplatin AUC 4 with cabazitaxel 20 mg/m2....

What is the current status of trial NCT03934840?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 22 participants. The study started on 2019-10-10. Estimated completion is 2025-05.

What conditions does trial NCT03934840 study?

This clinical trial studies the following conditions: Prostate Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03934840?

The interventions under investigation include: Carboplatin (DRUG), Prednisone (DRUG), Abiraterone (DRUG), Cabazitaxel (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03934840?

This trial is sponsored by Masonic Cancer Center, University of Minnesota, which has 154 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03934840 being conducted?

This trial has 8 study locations across Arizona, Illinois, Louisiana, Minnesota, Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial