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NCT03707262 · ClinicalTrials.gov registry record · Phase 1
Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor
A Phase 1 study of Kidney Transplant and Tolerance, sponsored by Jeffrey Veale, MD.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT03707262: Recruiting Phase 1 study of Kidney Transplant and Tolerance, sponsored by Jeffrey Veale, MD.
NCT03707262 is a Phase 1 study of Kidney Transplant and Tolerance that is actively recruiting participants, run by Jeffrey Veale, MD. The registered enrollment target is 15 participants, below the 1,898-participant average among 30 other Kidney Transplant trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03707262, a Phase 1 study of Kidney Transplant and Tolerance, is actively recruiting participants, sponsored by Jeffrey Veale, MD.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to find out if an investigational treatment will allow kidney transplant recipients to better accept their new kidney and stop immunosuppressive medicines. This study is for kidney transplant recipients who receive a kidney from a sibling donor. The investigational treatment is started after kidney transplant. It begins with a regimen of a drug called rabbit anti-thymocyte globulin (rATG) combined with radiation therapy (known as total lymphoid irradiation, or TLI) to the lymph nodes and spleen. This is followed by an infusion of blood stem cells, which will be donated by the same sibling who donated their kidney. Researchers think that this treatment allows immune cells from the donor and recipient to live side by side, a condition referred to as "mixed chimerism." Mixed chimerism may help create a state of "tolerance" in kidney transplant recipients in which all immunosuppressive medications can be stopped without rejection of the transplanted kidney. This study will test whether (1) the investigational treatment will allow patients to stop immunosuppressive medications after their kidney transplant and (2) if the treatment impacts the rate of kidney rejection and the side effects of immunosuppressive medications.
Primary Outcome
Percentage of subjects free from all immunosuppressive drugs at 12 months after kidney transplantation.
Conditions Studied
Interventions
- BIOLOGICAL Donor CD34+ and CD3+ cells
Study Locations (1)
California
- University of California, Los Angeles - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2019-11-06 |
| Est. Completion | 2026-02 |
| Phase | Phase 1 |
What NCT03707262 shows while recruiting
NCT03707262 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 1,898-participant average among 30 other Kidney Transplant trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Kidney Transplant appearing as the primary indexed condition, and to 1 intervention - of which Donor CD34+ and CD3+ cells is the first listed.
NCT03707262 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03707262 about?
NCT03707262 is a clinical study titled "Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor". The purpose of this study is to find out if an investigational treatment will allow kidney transplant recipients to better accept their new kidney and stop immunosuppressive medicines. This study is for kidney transplant recipients who receive a kidney from a sibling donor. The investigational trea...
What is the current status of trial NCT03707262?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2019-11-06. Estimated completion is 2026-02.
What conditions does trial NCT03707262 study?
This clinical trial studies the following conditions: Kidney Transplant, Tolerance, Renal Transplant Rejection.
What interventions are being tested in trial NCT03707262?
The interventions under investigation include: Donor CD34+ and CD3+ cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT03707262?
This trial is sponsored by Jeffrey Veale, MD, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03707262 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Kidney Transplant
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03707262's enrollment target sits among peer trials
15 26th of 30 higher than 4 of 30 other Kidney Transplant trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Kidney Transplant trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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