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COMPLETED Phase 2

A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression

NCT03559192 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the efficacy of JNJ-67953964 compared to placebo when administered as adjunctive treatment in participants with Major Depressive Disorder (MDD) partially responsive to selective serotonin reuptake inhibitor/ serotonin-norepinephrine reuptake inhibitor (SSRI/SNRI) treatment in terms of reduction of symptoms of depression, as assessed by the change from baseline on the Montgomery Asberg Depression Rating Scale (MADRS) in non-responders during the placebo lead-in period.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG JNJ-67953964

Study Locations (20)

California

  • Behavioral Research Specialists LLC — Glendale
  • NRC Research Institute — Orange
  • Artemis Institute for Clinical Research — Riverside
  • Artemis Institute for Clinical Research — San Marcos
  • Pacific Clinical Research Medical Group — Upland

Florida

  • Innova Clinical Trials — Miami
  • Galiz Research — Miami Springs
  • APG Research LLC — Orlando
  • Olympian Clinical Research — Tampa
  • Meridien Research — Tampa

Illinois

  • Chicago Research Center — Chicago
  • Psychiatric Medicine Associates LLC — Skokie

New York

  • Integrative Clinical Trials LLC — Brooklyn
  • Richmond Behavioural Associates — Staten Island

Arizona

  • Noble Clinical Research — Tucson

Arkansas

  • Preferred Research Partners — Little Rock

Georgia

  • Atlanta Behavioral Research, LLC — Atlanta

Louisiana

  • Lake Charles Clinical Trials — Lake Charles

Trial Details

FieldValue
Enrollment Target 181 participants
Start Date 2018-07-16
Est. Completion 2020-05-06
Phase Phase 2

Sponsor

Janssen Research & Development

442 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03559192

The ClinicalTrials.gov registry entry for NCT03559192 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 181 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Depressive Disorder, Major appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03559192 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03559192 about?

NCT03559192 is a clinical study titled "A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression". The purpose of this study is to evaluate the efficacy of JNJ-67953964 compared to placebo when administered as adjunctive treatment in participants with Major Depressive Disorder (MDD) partially responsive to selective serotonin reuptake inhibitor/ serotonin-norepinephrine reuptake inhibitor (SSRI/S...

What is the current status of trial NCT03559192?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 181 participants. The study started on 2018-07-16. Estimated completion is 2020-05-06.

What conditions does trial NCT03559192 study?

This clinical trial studies the following conditions: Depressive Disorder, Major. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03559192?

The interventions under investigation include: Placebo (DRUG), JNJ-67953964 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03559192?

This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03559192 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial