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ACTIVE NOT RECRUITING Phase 2

Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

NCT03516279 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies how well pembrolizumab and dasatinib, imatinib mesylate, or nilotinib work in treating patients with chronic myeloid leukemia and persistent detection of minimal residual disease, defined as the levels of a gene product called bcr-abl in the blood. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of cancer cells to grow and spread. Dasatinib, imatinib mesylate, and nilotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving pembrolizumab and dasatinib, imatinib mesylate, or nilotinib may work better in treating patients with chronic myeloid leukemia.

Interventions

  • BIOLOGICAL Pembrolizumab
  • OTHER Laboratory Biomarker Analysis
  • DRUG Dasatinib
  • DRUG Nilotinib
  • DRUG Imatinib Mesylate

Study Locations (20)

California

  • Mission Hope Medical Oncology - Arroyo Grande — Arroyo Grande
  • Mercy Cancer Center - Carmichael — Carmichael
  • Mercy San Juan Medical Center — Carmichael
  • Mercy Cancer Center - Elk Grove — Elk Grove
  • Contra Costa Regional Medical Center — Martinez
  • Mercy Cancer Center — Merced
  • Mercy Cancer Center - Rocklin — Rocklin
  • Mercy Cancer Center - Sacramento — Sacramento
  • Pacific Central Coast Health Center-San Luis Obispo — San Luis Obispo
  • Mission Hope Medical Oncology - Santa Maria — Santa Maria
  • BASS Medical Group - Lennon — Walnut Creek
  • Woodland Memorial Hospital — Woodland

Arkansas

  • Mercy Hospital Fort Smith — Fort Smith
  • CHI Saint Vincent Cancer Center Hot Springs — Hot Springs
  • CARTI Cancer Center — Little Rock

Arizona

  • CTCA at Western Regional Medical Center — Goodyear
  • Cancer Center at Saint Joseph's — Phoenix

Colorado

  • Rocky Mountain Cancer Centers-Aurora — Aurora
  • Boulder Community Foothills Hospital — Boulder

Alaska

  • Fairbanks Memorial Hospital — Fairbanks

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 2019-06-26
Est. Completion 2031-08-31
Phase Phase 2

Sponsor

ECOG-ACRIN Cancer Research Group

52 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03516279

The ClinicalTrials.gov registry entry for NCT03516279 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ECOG-ACRIN Cancer Research Group, which has 52 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Minimal Residual Disease appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03516279 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Arkansas, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03516279 about?

NCT03516279 is a clinical study titled "Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease". This phase II trial studies how well pembrolizumab and dasatinib, imatinib mesylate, or nilotinib work in treating patients with chronic myeloid leukemia and persistent detection of minimal residual disease, defined as the levels of a gene product called bcr-abl in the blood. Monoclonal antibodies, ...

What is the current status of trial NCT03516279?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2019-06-26. Estimated completion is 2031-08-31.

What conditions does trial NCT03516279 study?

This clinical trial studies the following conditions: Minimal Residual Disease, Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03516279?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Laboratory Biomarker Analysis (OTHER), Dasatinib (DRUG), Nilotinib (DRUG), Imatinib Mesylate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03516279?

This trial is sponsored by ECOG-ACRIN Cancer Research Group, which has 52 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03516279 being conducted?

This trial has 20 study locations across Alaska, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial