Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 3

A Study of Tislelizumab Versus Sorafenib in Participants With Unresectable Hepatocellular Carcinoma (HCC)

NCT03412773 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 3 study was a global, multicenter trial that randomly assigned participants to either tislelizumab or sorafenib as a first-line treatment for adults with advanced liver cancer (hepatocellular carcinoma) that could not be surgically removed. Before enrolling Japanese participants in the main Phase 3 study, a preliminary assessment of safety and tolerability (the Safety Run-In Sub-study) was conducted in Japan.

Interventions

  • DRUG Tislelizumab
  • DRUG Sorafenib

Study Locations (20)

Beijing Municipality

  • Cancer Hospital Chinese Academy of Medical Sciences — Beijing
  • Military Hospital of China — Beijing
  • Beijing Youan Hospital, Capital Medical University — Beijing
  • Beijing Cancer Hospital — Beijing
  • Peking Union Medical College Hospital — Beijing
  • Chinese Pla General Hospital — Beijing

Anhui

  • The First Affiliated Hospital of Bengbu Medical College — Bengbu
  • Anhui Provincial Hospital — Hefei
  • The First Affiliated Hospital of Anhui Medical University — Hefei
  • The Second Hospital of Anhui Medical University — Hefei

California

  • Providence Medical Foundation — Fullerton
  • UCLA Hematologyoncology — Los Angeles
  • Chao Family Comprehensive Cancer Center — Orange

Massachusetts

  • Massachusetts General Hospital — Boston

New Jersey

  • Umdnj Njms — Newark

New York

  • Rj Zuckerberg Cancer Center — Lake Success

Ohio

  • Xcancerdayton Physician Network — Dayton

Tennessee

  • Vanderbilt University Medical Center — Nashville

Trial Details

FieldValue
Enrollment Target 684 participants
Start Date 2017-12-18
Est. Completion 2023-12-14
Phase Phase 3

Sponsor

BeiGene

91 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03412773

The ClinicalTrials.gov registry entry for NCT03412773 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 684 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeiGene, which has 91 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hepatocellular Carcinoma (HCC) appearing as the primary indexed condition, and to 2 interventions — of which Tislelizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03412773 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Beijing Municipality, Anhui, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03412773 about?

NCT03412773 is a clinical study titled "A Study of Tislelizumab Versus Sorafenib in Participants With Unresectable Hepatocellular Carcinoma (HCC)". This Phase 3 study was a global, multicenter trial that randomly assigned participants to either tislelizumab or sorafenib as a first-line treatment for adults with advanced liver cancer (hepatocellular carcinoma) that could not be surgically removed. Before enrolling Japanese participants in the ma...

What is the current status of trial NCT03412773?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 684 participants. The study started on 2017-12-18. Estimated completion is 2023-12-14.

What conditions does trial NCT03412773 study?

This clinical trial studies the following conditions: Hepatocellular Carcinoma (HCC). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03412773?

The interventions under investigation include: Tislelizumab (DRUG), Sorafenib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03412773?

This trial is sponsored by BeiGene, which has 91 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03412773 being conducted?

This trial has 20 study locations across California, Massachusetts, New Jersey, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial