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Treatment of Refractory Nausea and Vomiting in Patients With Breast Cancer
NCT03367572 · View on ClinicalTrials.gov ↗
Study Summary
This randomized phase III trial studies how well netupitant/palonosetron hydrochloride and dexamethasone with prochlorperazine or olanzapine work compared to netupitant/palonosetron hydrochloride and dexamethasone in improving chemotherapy-induced nausea and vomiting in patients with breast cancer. Antiemetic drugs, such as prochlorperazine and olanzapine, may help lessen nausea and vomiting in patients with breast cancer treated with chemotherapy.
Conditions Studied
Interventions
- OTHER Placebo
- OTHER Laboratory Biomarker Analysis
- DRUG Dexamethasone
- DRUG Olanzapine
- DRUG Netupitant/Palonosetron Hydrochloride
Study Locations (18)
Wisconsin
- Saint Vincent Hospital Cancer Center Green Bay — Green Bay
- Gundersen Health System — La Crosse
- Aurora NCORP — Milwaukee
Michigan
- Michigan Cancer Research Consortium — Ann Arbor
- Cancer Research Consortium of West Michigan — Grand Rapids
Ohio
- Columbus NCORP — Columbus
- Dayton Clinical Oncology Program — Dayton
South Carolina
- Greenville NCORP — Greenville
- Upstate Carolina NCORP — Spartanburg
Hawaii
- Hawaii MU NCORP — Honolulu
Illinois
- Decatur Memorial Hospital — Decatur
Louisiana
- Gulf South MU-NCORP — New Orleans
Minnesota
- Health Partners Inc — Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,363 participants |
| Start Date | 2018-04-19 |
| Est. Completion | 2024-04-13 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03367572
The ClinicalTrials.gov registry entry for NCT03367572 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,363 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Rochester NCORP Research Base, which has 8 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Breast Carcinoma appearing as the primary indexed condition, and to 5 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03367572 reports 18 study locations spanning 13 distinct geographic areas — top geographies include Wisconsin, Michigan, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03367572 about?
NCT03367572 is a clinical study titled "Treatment of Refractory Nausea and Vomiting in Patients With Breast Cancer". This randomized phase III trial studies how well netupitant/palonosetron hydrochloride and dexamethasone with prochlorperazine or olanzapine work compared to netupitant/palonosetron hydrochloride and dexamethasone in improving chemotherapy-induced nausea and vomiting in patients with breast cancer. ...
What is the current status of trial NCT03367572?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 1,363 participants. The study started on 2018-04-19. Estimated completion is 2024-04-13.
What conditions does trial NCT03367572 study?
This clinical trial studies the following conditions: Breast Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03367572?
The interventions under investigation include: Placebo (OTHER), Laboratory Biomarker Analysis (OTHER), Dexamethasone (DRUG), Olanzapine (DRUG), Netupitant/Palonosetron Hydrochloride (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03367572?
This trial is sponsored by University of Rochester NCORP Research Base, which has 8 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03367572 being conducted?
This trial has 18 study locations across Hawaii, Illinois, Louisiana, Michigan, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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