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REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)
NCT03185013 · View on ClinicalTrials.gov ↗
Study Summary
HPV-301 is a prospective, randomized, double-blind, placebo controlled Phase 3 study to determine the efficacy, safety, and tolerability of VGX-3100 administered by intramuscular (IM) injection followed by electroporation (EP) delivered with CELLECTRA™ 5PSP in adult women with histologically confirmed cervical high grade squamous intraepithelial lesion (HSIL) (cervical intraepithelial neoplasia grade 2 \[CIN2\] or grade 3 \[CIN3\]) associated with human papillomavirus (HPV) 16 and/or HPV-18.
Conditions Studied
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL VGX-3100
- DEVICE Electroporation (EP)
Study Locations (20)
Florida
- Women's Medical Research Group — Clearwater
- Altus Research — Lake Worth
- Salom and Tangir LLC — Miramar
- Comprehensive Clinical Trials LLC — West Palm Beach
Arizona
- Mesa Obstetricians and Gynecologist — Mesa
- Women's Health Research — Scottsdale
- Visions Clinical Research-Tucson — Tucson
New York
- Columbia University Medical Center — New York
- Suffolk Obstetrics and Gynecology — Port Jefferson
South Carolina
- Greenville Pharmaceutical Research, Inc. — Greenville
- Magnolia Ob/Gyn Research Center, LLC — Myrtle Beach
Tennessee
- Chattanooga Medical Research Inc — Chattanooga
- Women's Physician Group — Memphis
Georgia
- Augusta University — Augusta
Louisiana
- Praetorian Pharmaceutical Research, LLC — Marrero
Michigan
- Saginaw Valley Medical Research Group LLC — Saginaw
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 201 participants |
| Start Date | 2017-06-28 |
| Est. Completion | 2021-04-06 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03185013
The ClinicalTrials.gov registry entry for NCT03185013 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 201 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Inovio Pharmaceuticals, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Cervical Dysplasia appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03185013 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Florida, Arizona, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03185013 about?
NCT03185013 is a clinical study titled "REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)". HPV-301 is a prospective, randomized, double-blind, placebo controlled Phase 3 study to determine the efficacy, safety, and tolerability of VGX-3100 administered by intramuscular (IM) injection followed by electroporation (EP) delivered with CELLECTRA™ 5PSP in adult women with histologically confirm...
What is the current status of trial NCT03185013?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 201 participants. The study started on 2017-06-28. Estimated completion is 2021-04-06.
What conditions does trial NCT03185013 study?
This clinical trial studies the following conditions: Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion, HSIL. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03185013?
The interventions under investigation include: Placebo (BIOLOGICAL), VGX-3100 (BIOLOGICAL), Electroporation (EP) (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03185013?
This trial is sponsored by Inovio Pharmaceuticals, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03185013 being conducted?
This trial has 20 study locations across Arizona, Florida, Georgia, Louisiana, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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